دورية أكاديمية
Per-lesion versus per-patient analysis of coronary artery disease in predicting the development of obstructive lesions: the Progression of AtheRosclerotic PlAque DetermIned by Computed TmoGraphic Angiography Imaging (PARADIGM) study
| العنوان: | Per-lesion versus per-patient analysis of coronary artery disease in predicting the development of obstructive lesions: the Progression of AtheRosclerotic PlAque DetermIned by Computed TmoGraphic Angiography Imaging (PARADIGM) study |
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| المؤلفون: | Lee, S.E., Sung, J.M., Andreini, D., Al-Mallah, M.H., Budoff, M.J., Cademartiri, F., Chinnaiyan, K., Choi, J.H., Chun, E.J., Conte, E., Gottlieb, I., Hadamitzky, M., Kim, Y.J., Lee, B.K., Leipsic, J.A., Maffei, E., Marques, H., Goncalves, P.D., Pontone, G., Shin, S., Stone, P.H., Samady, H., Virmani, R., Narula, J., Berman, D.S., Shaw, L.J., Bax, J.J., Lin, F.Y., Min, J.M.K., Chang, H.J. |
| المصدر: | International Journal of Cardiovascular Imaging |
| سنة النشر: | 2020 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | Coronary artery disease, Coronary artery atherosclerosis, Statins, Coronary computed tomography angiography |
| الوصف: | To determine whether the assessment of individual plaques is superior in predicting the progression to obstructive coronary artery disease (CAD) on serial coronary computed tomography angiography (CCTA) than per-patient assessment. From a multinational registry of 2252 patients who underwent serial CCTA at a >= 2-year inter-scan interval, patients with only non-obstructive lesions at baseline were enrolled. CCTA was quantitatively analyzed at both the per-patient and per-lesion level. Models predicting the development of an obstructive lesion at follow up using either the per-patient or per-lesion level CCTA measures were constructed and compared. From 1297 patients (mean age 60 +/- 9 years, 43% men) enrolled, a total of 3218 non-obstructive lesions were identified at baseline. At follow-up (inter-scan interval: 3.8 +/- 1.6 years), 76 lesions (2.4%, 60 patients) became obstructive, defined as > 50% diameter stenosis. The C-statistics of Model 1, adjusted only by clinical risk factors, was 0.684. The addition of per-patient level total plaque volume (PV) and the presence of high-risk plaque (HRP) features to Model 1 improved the C-statistics to 0.825 [95% confidence interval (CI) 0.823-0.827]. When per-lesion level PV and the presence of HRP were added to Model 1, the predictive value of the model improved the C-statistics to 0.895 [95% CI 0.893-0.897]. The model utilizing per-lesion level CCTA measures was superior to the model utilizing per-patient level CCTA measures in predicting the development of an obstructive lesion (p < 0.001). Lesion-level analysis of coronary atherosclerotic plaques with CCTA yielded better predictive power for the development of obstructive CAD than the simple quantification of total coronary atherosclerotic burden at a per-patient level. ; Cardiology |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | lumc-id: 115688593; https://hdl.handle.net/1887/3232666Test |
| DOI: | 10.1007/s10554-020-01960-z |
| الإتاحة: | https://doi.org/10.1007/s10554-020-01960-zTest https://hdl.handle.net/1887/3232666Test |
| رقم الانضمام: | edsbas.C02AF238 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10554-020-01960-z |
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