التفاصيل البيبلوغرافية
| العنوان: |
Sex differences among patients receiving ticagrelor monotherapy or aspirin after coronary bypass surgery: A prespecified subgroup analysis of the TiCAB trial. |
| المؤلفون: |
Sandner, Sigrid1 (AUTHOR) sigrid.sandner@meduniwien.ac.at, Kastrati, Adnan2,3 (AUTHOR), Niessner, Alexander4 (AUTHOR), Böning, Andreas5 (AUTHOR), Zeymer, Uwe6 (AUTHOR), Conradi, Lenard7 (AUTHOR), Danner, Bernhard8 (AUTHOR), Zimpfer, Daniel9 (AUTHOR), Färber, Gloria10 (AUTHOR), Manville, Emely1 (AUTHOR), Schunkert, Heribert2,3 (AUTHOR), von Scheidt, Moritz2,3 (AUTHOR) |
| المصدر: |
International Journal of Cardiology. Jan2023, Vol. 370, p129-135. 7p. |
| مصطلحات موضوعية: |
*CORONARY artery bypass, *DRUG-eluting stents, *ASPIRIN, *TICAGRELOR, *SUBGROUP analysis (Experimental design), CARDIOVASCULAR disease related mortality |
| مستخلص: |
There is limited evidence on the association of sex with outcomes among patients undergoing coronary bypass surgery (CABG) and treated with ticagrelor monotherapy or aspirin. This was a pre-specified sub-analysis of TiCAB, an investigator-initiated placebo-controlled randomized trial. Primary efficacy endpoint was the composite of cardiovascular death, myocardial infarction, stroke, or repeat revascularization 1 year after CABG. Safety endpoint was BARC type 2, 3 or 5 bleeding. A total of 280 (15.0%) women and 1579 (85.0%) men were included. Compared with men, women were older (66.1 ± 10.2 vs. 70.1 ± 9.3 years) with more acute presentation (17.0% vs 21.1%). The incidence of the primary endpoint was similar between women and men (9.2% vs. 8.9%, HR 1.08, 95%CI 0.71–1.66, P = 0.71). Cardiovascular death occurred more often in women (2.9% vs 1.0%, adjusted HR 2.87, 95%CI 1.23–6.70, P = 0.02). The incidence of bleeding was similar between the sexes (2.2% vs. 2.5%, HR 0.91, 95% CI 0.51–1.65, P = 0.77). Ticagrelor vs aspirin was associated with a similar risk of the primary endpoint in women (10.6% vs. 7.9%, HR 1.39, 95%CI 0.63–3.05, P = 0.42) and men (9.5% vs. 8.2%, HR 1.15, 95%CI 0.82–1.62, P = 0.41;p interaction = 0.69), and a similar risk of bleeding in women (2.9% vs. 1.4%, HR 2.09, 95%CI 0.38–11.41, P = 0.40) and men (2.2% vs. 2.8%, HR 0.80, 95%CI 0.42–1.52, P = 0.49;p interaction = 0.35). Among women and men undergoing CABG, ticagrelor monotherapy was associated with a similar risk of the primary efficacy endpoint and bleeding compared with aspirin. The risk of cardiovascular death was increased in women irrespective of antiplatelet therapy. • There are significant baseline risk differences between women and men undergoing CABG. • Ticagrelor and aspirin were associated with a similar risk of CV death, MI, stroke, or revascularization in women and men. • Ticagrelor and aspirin were associated with a similar risk of clinically important bleeding events in women and men. • Women had a higher risk of CV death 30 days and 1 year after CABG irrespective of type of antiplatelet therapy. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
