Preconditioning with high mobility group box 1 protein protects against myocardial ischemia–reperfusion injury
| العنوان: | Preconditioning with high mobility group box 1 protein protects against myocardial ischemia–reperfusion injury |
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| المؤلفون: | Hong Jiang, Bo He, Changwu Xu, Bo Cui, Zhibing Lu, Xiaorong Hu |
| المصدر: | International Journal of Cardiology |
| بيانات النشر: | Elsevier Ireland Ltd., 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Myocardial ischemia, chemical and pharmacologic phenomena, Cardioprotection, HMGB1, Article, chemistry.chemical_compound, Ischemia, Internal medicine, Lactate dehydrogenase, medicine, biology, business.industry, Infarct size, medicine.disease, High-mobility group, chemistry, Anesthesia, Reperfusion, biology.protein, Cardiology, Creatine kinase, Tumor necrosis factor alpha, High mobility group box 1 protein, Cardiology and Cardiovascular Medicine, business, Reperfusion injury |
| الوصف: | Objective To investigate whether preconditioning with high mobility group box 1 protein (HMGB1) could reduce myocardial ischemia–reperfusion (I/R) injury. Methods and results Infarct size, lactate dehydrogenase (LDH), creatine kinase (CK), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were assessed. HMGB1 preconditioning reduced significantly the infarct size induced by I/R. The LDH, CK, TNF-α and IL-6 levels were significantly decreased by HMGB1 preconditioning compared to those in the I/R group. Conclusion The present study suggested that preconditioning with HMGB1 could induce HMGB1 tolerance and protect against myocardial I/R injury. |
| اللغة: | English |
| تدمد: | 1874-1754 0167-5273 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6220e8074c6dc9865bb923d9e4b606Test http://europepmc.org/articles/PMC7132366Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6e6220e8074c6dc9865bb923d9e4b606 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18741754 01675273 |
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