التفاصيل البيبلوغرافية
| العنوان: |
Similarities between ischemic preconditioning and postconditioning in myocardial ischemia/reperfusion injury |
| المؤلفون: |
Hu, Xiaorong1, Jiang, Hong jianghong58@gmail.com, Ma, Fenna1, Xu, Changwu1, Bo, Cui1, Wen, Huazhi1, Wu, Bing1, Lu, Zhibing1 |
| المصدر: |
International Journal of Cardiology. Sep2010, Vol. 144 Issue 1, p135-136. 2p. |
| مصطلحات موضوعية: |
*CORONARY heart disease prevention, *REPERFUSION injury, *THERAPEUTICS, *LACTATE dehydrogenase, *MYOCARDIUM, *APOPTOSIS, *SUPEROXIDE dismutase, *CREATINE kinase |
| مستخلص: |
Abstract: Objective: To determine whether a combination of ischemic preconditioning (IPreC) and ischemic postconditioning (IPostC) provided synergistic protection in myocardial ischemia/reperfusion injury. Methods and results: IPreC and IPostC could not provide synergistically protective effects on reducing infarct size, inhibiting the increase of lactate dehydrogenase, creatine kinase and malondialdehyde and inhibiting the decrease of superoxide dismutase, and inhibiting myocardium apoptosis induced by ischemia/reperfusion. Conclusion: The present study indicated that the combination of IPreC and IPostC could not provide a synergistic protection in myocardial 1ischemia/reperfusion injury, they may share common signaling pathways. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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