Fluropyrimidine single agent or doublet chemotherapy as second line treatment in advanced biliary tract cancer
| العنوان: | Fluropyrimidine single agent or doublet chemotherapy as second line treatment in advanced biliary tract cancer |
|---|---|
| المؤلفون: | Giuseppe Aprile, Anne-Laure Pointet, Mario Scartozzi, Astrid Lièvre, David Tougeron, Ludovic Evesque, Angélique Vienot, Sara Lonardi, Samuel Le Sourd, Bertrand Brieau, Nicola Silvestris, Dewi Vernerey, Laetitia Dahan, Gico Investigators, Benoit Rousseau, Cindy Neuzillet, Aurélia Meurisse, Giovanni Brandi, Caterina Vivaldi, Andrea Casadei-Gardini, Ageo investigators, Roberto Filippi |
| المساهمون: | Institut Curie [Paris], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Pisa - Università di Pisa, Policlinico S. Orsola-malpighi, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Servizio sanitario regionale Emilia-Romagna, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Università degli studi di Torino = University of Turin (UNITO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), CHU Henri Mondor [Créteil], Università degli Studi di Cagliari = University of Cagliari (UniCa), Hôpital de la Timone [CHU - APHM] (TIMONE), Università degli Studi di Udine - University of Udine [Italie], CRLCC Eugène Marquis (CRLCC), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuzillet, C., Casadei Gardini, A., Brieau, B., Vivaldi, C., Brandi, G., Tougeron, D., Filippi, R., Vienot, A., Silvestris, N., Pointet, A. -L., Lonardi, S., Rousseau, B., Scartozzi, M., Dahan, L., Aprile, G., Le Sourd, S., Evesque, L., Meurisse, A., Lievre, A., Vernerey, D., CHU Henri Mondor, Jonchère, Laurent, Neuzillet C., Casadei-Gardini A., Brieau B., Vivaldi C., Brandi G., Tougeron D., Filippi R., Vienot A., Silvestris N., Pointet A.-L., Lonardi S., Rousseau B., Scartozzi M., Dahan L., Aprile G., Le Sourd S., Evesque L., Meurisse A., Lievre A., Vernerey D., Università degli Studi di Modena e Reggio Emilia, Università degli studi di Torino (UNITO), Università degli studi di Bari Aldo Moro (UNIBA), Universita degli Studi di Cagliari [Cagliari], Université Côte d'Azur (UCA)-UNICANCER, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | International Journal of Cancer International Journal of Cancer, 2020, 147 (11), pp.3177-3188. ⟨10.1002/ijc.33146⟩ International Journal of Cancer, Wiley, 2020, 147 (11), pp.3177-3188. ⟨10.1002/ijc.33146⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, overall survival, [SDV.CAN]Life Sciences [q-bio]/Cancer, Irinotecan, cholangiocarcinoma, combination chemotherapy, monotherapy, palliative chemotherapy, Aged, Antineoplastic Combined Chemotherapy Protocols, Bile Duct Neoplasms, Capecitabine, Female, Fluorouracil, France, Humans, Italy, Middle Aged, Platinum, Prospective Studies, Pyrimidines, Retrospective Studies, Survival Analysis, Treatment Outcome, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Chemotherapy, Performance status, business.industry, Combination chemotherapy, cholangiocarcinoma, combination chemotherapy, monotherapy, overall survival, palliative chemotherapy, Gemcitabine, 3. Good health, Oxaliplatin, Regimen, 030220 oncology & carcinogenesis, Cohort, business, medicine.drug |
| الوصف: | International audience; Fluoropyrimidine (FP) plus platinum chemotherapy has been recently established as a second-line (L2) preferred option in advanced biliary tract cancer (aBTC) (ABC-06 phase III trial). However, the overall survival (OS) benefit was limited and comparison with FP monotherapy was not available. Our aim was to assess the OS of patients treated with a FP monotherapy compared to a doublet with irinotecan or platinum in L2. We performed a retrospective analysis of two large multicenter prospective cohorts: a French cohort (28 centers) and an Italian cohort (9 centers). All consecutive patients with aBTC receiving FP-based L2 after gemcitabine plus cisplatin/gemcitabine plus oxaliplatin L1 between 2003 and 2016 were included. A subgroup analysis according to performance status (PS) and an exploratory analysis according to platinum sensitivity in L1 were planned. In the French cohort (n = 351), no significant OS difference was observed between the FP monotherapy and doublet groups (median OS: 5.6 vs 6.8 months, P = .65). Stratification on Eastern Cooperative Oncology Group (ECOG) PS showed similar results in PS 0-1 and 2. Median OS was not different between FP monotherapy, platinum- and irinotecan-based doublets (5.6 vs 7.1 vs 6.7 months, P = .68). Similar findings were observed in the Italian cohort (n = 174) and in the sensitivity analysis in pooled cohorts (n = 525). No L2 regimen seemed superior over others in the platinum resistant/refractory or sensitive subgroups. Our results suggest that FP monotherapy is as active as FP doublets in aBTC in L2, regardless of the patient PS and country, and could be a therapeutic option in this setting. |
| وصف الملف: | application/pdf; STAMPA |
| تدمد: | 1097-0215 0020-7136 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0845ac06765b2fd49c595f624a1cf498Test https://pubmed.ncbi.nlm.nih.gov/32525595Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0845ac06765b2fd49c595f624a1cf498 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
|---|