Hypoxia-inducible factor-1? in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
| العنوان: | Hypoxia-inducible factor-1? in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways |
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| المؤلفون: | Kenneth J. O'Byrne, Daniel E.B. Swinson, Adrian L. Harris, J. Louise Jones, Donna Richardson, Giles Cox |
| المصدر: | International Journal of Cancer. 111:43-50 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Hypoxia-Inducible Factor 1, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Apoptosis, Necrosis, Hypoxia-Inducible Factor 1-Alpha, Epidermal growth factor, Carcinoma, Non-Small-Cell Lung, Internal medicine, Biomarkers, Tumor, medicine, Humans, Epidermal growth factor receptor, Lung cancer, Aged, Carbonic Anhydrases, Neoplasm Staging, G alpha subunit, biology, Growth factor, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, medicine.disease, Immunohistochemistry, Cell Hypoxia, ErbB Receptors, Gene Expression Regulation, Neoplastic, Cross-Sectional Studies, Endocrinology, Matrix Metalloproteinase 9, Oncology, Cancer research, biology.protein, Female, Tumor necrosis factor alpha, Transcription Factors |
| الوصف: | Hypoxia-inducible factor (HIF)-1 alpha is the regulatory subunit of HIF-1 that is stabilized under hypoxic conditions. Under different circumstances, HIF-1 alpha may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF-1 alpha as a prognostic factor. This study evaluated HIF-1 alpha expression in 172 consecutive patients with stage I-IIIA non small cell lung cancer (NSCLC) using standard immunohistochemical techniques. The extent of HIF-1 alpha nuclear immunostaining was determined using light microscopy and the results were analyzed using the median (5%) as a low cut-point and 60% as a high positive cut-point. Using the low cut-point, positive associations were found with epidermal growth factor receptor (EGFR; p = 0.01), matrix metalloproteinase (MMP)-9 (p = 0.003), membranous (p < 0.001) and perinuclear (p = 0.004) carbonic anhydrase (CA) IX, p53 (p = 0.008), T-stage (p = 0.042), tumor necrosis (TN; p < 0.001) and squamous histology (p < 0.001). No significant association was found with Bcl-2 or either N- or overall TMN stage or prognosis. When the high positive cut-point was used, HIF-1 alpha was associated with a poor prognosis (p = 0.034). In conclusion, the associations with EGFR, MMP-9, p53 and CA IX suggest that these factors may either regulate or be regulated by HIF-1 alpha. The association with TN and squamous-type histology, which is relatively more necrotic than other NSCLC types, reflects the role of hypoxia in the regulation of HIF-1 alpha. The prognostic data may reflect a change in the behavior of HIF-1 alpha in increasingly hypoxic environments. |
| تدمد: | 1097-0215 0020-7136 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b9a6abf8f2280d4f473bf0bb4eec2cTest https://doi.org/10.1002/ijc.20052Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a5b9a6abf8f2280d4f473bf0bb4eec2c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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