التفاصيل البيبلوغرافية
| العنوان: |
Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients |
| المؤلفون: |
Olga V. Gurova, Svetlana V. Khlgatian, Alexander Knuth, Maria A. Lagarkova, Ksenia E. Kuz'mina, Boris V. Radko, Elke Jäger, Mikhail Lichinitser, P. V. Belousov, Dmitry V. Kuprash, Ekaterina P. Koroleva, Sergei A. Nedospasov, Fanny Longpre, Yuriy V. Shebzukhov, Tatiana S. Kadachigova, Andrey Meshcheryakov |
| المصدر: |
International journal of cancer. 117(5) |
| سنة النشر: |
2005 |
| مصطلحات موضوعية: |
Cancer Research, Colorectal cancer, Antibodies, Neoplasm, Blotting, Western, Molecular Sequence Data, Epitope, Histone Deacetylases, Epitopes, Antigen, Immunoscreening, medicine, Humans, Amino Acid Sequence, DNA Primers, B-Lymphocytes, biology, Base Sequence, Sequence Homology, Amino Acid, Histone deacetylase 2, fungi, Cancer, medicine.disease, Oncology, Immunology, Colonic Neoplasms, biology.protein, Histone deacetylase, Antibody |
| الوصف: |
Antibodies to cancer antigens can often be detected in the sera of patients, although the mechanism of the underlying humoral immune response is poorly understood. Using immunoscreening of tumor-derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen in colon cancer. Closely related HDAC1 and HDAC2 do not elicit humoral response in colon cancer patients. We show that the C-terminal region of HDAC3 protein lacking the homology to other Class I HDAC contains at least 3 distinct B-cell epitopes that are recognized by the serum antibodies. HDAC3 in combination with other SEREX antigens may become a useful molecular biomarker with diagnostic or prognostic value for a subset of colon cancer patients. Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscienceTest. wiley.com/jpages/0020-7136/suppmat/index.html. © 2005 Wiley-Liss, Inc. |
| تدمد: |
0020-7136 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406e18cde1b7547ea9ce63b54dfbead9Test
https://pubmed.ncbi.nlm.nih.gov/15981215Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....406e18cde1b7547ea9ce63b54dfbead9 |
| قاعدة البيانات: |
OpenAIRE |
