Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters
| العنوان: | Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters |
|---|---|
| المؤلفون: | Cataldo Di Bisceglie, Carlo Gazzera, Matteo Baldi, Angela Bertagna, Chiara Manieri, Giovanni Gandini, M. Tagliabue, Fabio Lanfranco |
| المصدر: | International Journal of Andrology. 30:531-536 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Time Factors, Adolescent, Urology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Varicocele, Polidocanol, Semen, Semen analysis, Biology, Polyethylene Glycols, Male infertility, Andrology, Sclerotherapy, medicine, Humans, Inhibins, Testosterone, Spermatogenesis, Sperm motility, Ultrasonography, Doppler, Duplex, Sperm Count, medicine.diagnostic_test, Phlebography, medicine.disease, Sclerosing Solutions, Spermatozoa, Sperm, Treatment Outcome, Reproductive Medicine, Case-Control Studies, Sperm Motility, Follicle Stimulating Hormone |
| الوصف: | The usefulness of treating varicocele in order to improve fertility is still a matter of debate. The aim of this study was to evaluate variations in seminal parameters and inhibin B concentrations in a group of males affected by varicocele and treated by percutaneous retrograde sclerotherapy in comparison with a group of patients who did not undergo varicocele treatment. Thirty-eight patients with left varicocele underwent spermatic vein phlebography and percutaneous retrograde sclerotherapy with hydroxy-polyaethoxy-dodecanol. Serum inhibin B, follicle-stimulating hormone (FSH), testosterone levels and seminal parameters (sperm concentration, motility and morphology) were performed before and 6 months after sclerotherapy. Forty patients with left varicocele who did not undergo sclerotherapy were studied as controls. A significant increase (p < 0.01) in serum inhibin B levels and a significant decrease (p < 0.05) in FSH levels were observed 6 months after treatment. Semen analysis showed a significant improvement in sperm concentration (p < 0.05) and progressive motility (p < 0.01) after treatment. In control group no significant variations in hormonal and seminal parameters were observed 6 months after the basal examination. Six months after the basal evaluation, inhibin B levels were significantly higher in treated subjects than in controls (p < 0.05) whereas FSH levels were significantly lower (p < 0.05). Sperm concentration and progressive motility were significantly increased (p < 0.05 and p < 0.001, respectively) in treated subjects in comparison with controls. In conclusion, varicocele sclerotherapy improves inhibin B levels and seminal parameters, confirming the positive effect of this treatment on spermatogenesis and Sertoli cell function. |
| تدمد: | 1365-2605 0105-6263 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a332b7d84976ba9b164effdfbd999a7fTest https://doi.org/10.1111/j.1365-2605.2007.00747.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a332b7d84976ba9b164effdfbd999a7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652605 01056263 |
|---|