Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner
| العنوان: | Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner |
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| المؤلفون: | C.J. Carter |
| المصدر: | International Journal of Alzheimer's Disease, Vol 2010 (2010) International Journal of Alzheimer's Disease |
| بيانات النشر: | Hindawi Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Aging, Gene knockdown, Clusterin, Article Subject, Cognitive Neuroscience, Complement receptor 1, Disease, Biology, lcsh:Geriatrics, Virology, Virus, PICALM, lcsh:RC321-571, Behavioral Neuroscience, Cellular and Molecular Neuroscience, lcsh:RC952-954.6, Neurology, Immunology, biology.protein, Neurology (clinical), biology.gene, Decoy receptors, Antibody, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Research Article |
| الوصف: | Herpes simplex is implicated in Alzheimer's disease and viral infection produces Alzheimer's disease like pathology in mice. The virus expresses proteins containing short contiguous amino acid stretches (5–9aa “vatches” = viralmatches) homologous to APOE4, clusterin, PICALM, and complement receptor 1, and to over 100 other gene products relevant to Alzheimer's disease, which are also homologous to proteins expressed by other pathogens implicated in Alzheimer's disease. Such homology, reiterated at the DNA level, suggests that gene association studies have been tracking infection, as well as identifying key genes, demonstrating a role for pathogens as causative agents. Vatches may interfere with the function of their human counterparts, acting as dummy ligands, decoy receptors, or via interactome interference. They are often immunogenic, and antibodies generated in response to infection may target their human counterparts, producing protein knockdown, or generating autoimmune responses that may kill the neurones in which the human homologue resides, a scenario supported by immune activation in Alzheimer's disease. These data may classify Alzheimer's disease as an autoimmune disorder created by pathogen mimicry of key Alzheimer's disease-related proteins. It may well be prevented by vaccination and regular pathogen detection and elimination, and perhaps stemmed by immunosuppression or antibody adsorption-related therapies. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2090-0252 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a09c5c1546c4606808c24e3054000d8Test https://doaj.org/article/879dc6a16ce24a05ba17201a3a7adadfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8a09c5c1546c4606808c24e3054000d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20900252 |
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