التفاصيل البيبلوغرافية
| العنوان: |
Clinical Features and Immunological Markers of Atopic Dermatitis in Elderly Patients. |
| المؤلفون: |
Bozek, Andrzej, Fisher, Andreas, Filipowska, Barbara, Mazur, Bogdan, Jarzab, Jerzy |
| المصدر: |
International Archives of Allergy & Immunology; Mar2012, Vol. 157 Issue 4, p372-378, 7p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
BIOMARKERS, ATOPIC dermatitis, STAPHYLOCOCCUS aureus, IMMUNOGLOBULINS, CYTOKINES, DISEASES in older people |
| مستخلص: |
Background: Atopic dermatitis (AD) is increasing among the elderly. Staphylococcus aureus colonization is one of the most important aggravating factors in AD. Objective: This study analyses the clinical features of AD in elderly patients and determines the pathogenic roles of staphylococcal superantigens in AD with low and high total IgE levels. Methods:S. aureus enterotoxin genes were evaluated using PCR. Additionally, S. aureus-specific IgE levels and peripheral blood lymphocyte profiles were assessed. Results: A total of 44 women and 77 men diagnosed with AD with a mean age of 68.92 ± 6.51 years were evaluated. In 17 (68%) patients with AD and low levels of total IgE, there was a positive correlation between the positive results for enterotoxin B, S. aureus-specific IgE antibodies and Th1 cytokine profiles (Spearman's rank correlation test, r = 0.89, p < 0.05). Conclusion: Our results indicate that AD patients with low total IgE levels differ in immunopathogenesis from AD patients with high circulating levels of total IgE AD. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
