التفاصيل البيبلوغرافية
| العنوان: |
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old. |
| المؤلفون: |
Pastorello, Elide Anna, Borgonovo, Linda, Preziosi, Donatella, Schroeder, Jan Walter, Pravettoni, Valerio, Aversano, Maria Gloria, Pastori, Stefano, Bilò, Maria Beatrice, Piantanida, Marta, Losappio, Laura Michelina, Nichelatti, Michele, Rossi, Carlo Maria, Farioli, Laura |
| المصدر: |
International Archives of Allergy & Immunology; 2021, Vol. 182 Issue 2, p146-152, 7p |
| مصطلحات موضوعية: |
TRYPTASE, HYPERCHOLESTEREMIA, HYMENOPTERA, ANAPHYLAXIS, GENDER, ATOPY, VENOM hypersensitivity |
| مستخلص: |
Introduction: Allergy to Hymenoptera venom (HV) may lead to life-threatening anaphylaxis. Some of the factors influencing the symptom's severity are still undetermined. The aim of this study was to identify the clinical aspects associated with the most severe reactions in a population with HV allergy, by comparing clinical and immunochemical biomarkers between patients with previous local large reactions (LLRs) and systemic reactions (SRs). Methods: We selected adult patients with a history of HV allergy, with positive diagnostic tests and a correlation with one single Hymenoptera species. Age, gender, atopy, serum basal tryptase (sBT) value, total IgE, venom-specific IgE, history of hypertension, cardiovascular diseases, and hypercholesterolemia were compared between patients with previous LLRs and SRs. Results: 460 adult patients (381 SRs, 79 LLRs) were included. Age (p = 0.0097), male gender (p < 0.0001), arterial hypertension (p = 0.046), hypercholesterolemia (p = 0.009), and higher sBT levels (p = 0.0004) were significantly associated with severe reactions as independent variables. Moreover, considering the previous variables as risk factors, there was a significant and progressive increase in the odds of being Mueller III + IV as the number of positive variables increased. Patients with sBT ≥6.4 ng/mL adjusted for any of the positive variables had increased the risk of Mueller grade IV reaction (p < 0.0001). Conclusion: According to our results, older age, male gender, arterial hypertension, hypercholesterolemia, and increased levels of sBT ≥6.4 ng/mL are risk factors for severe anaphylaxis to HV in adults. Atopy and allergic asthma do not increase the risk of HV-induced SRs. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
