Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome
| العنوان: | Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome |
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| المؤلفون: | Xiangling Wang, Pengfei Dai, Man Li, Dongsha Shi, Yanying Dong, Ming Xie |
| المصدر: | Internal and Emergency Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Severity of Illness Index, Blood Urea Nitrogen, Pathogenesis, chemistry.chemical_compound, Internal Medicine, Humans, Medicine, Blood urea nitrogen, Creatinine, Kidney, Proteinuria, Tumor Necrosis Factor-alpha, business.industry, Receptors, Tumor Necrosis Factor, Member 6b, Case-control study, virus diseases, HTNV, Im - Original, medicine.anatomical_structure, chemistry, TNF-α, Case-Control Studies, Hemorrhagic Fever with Renal Syndrome, Immunology, Emergency Medicine, Tumor necrosis factor alpha, Decoy receptor 3, DcR3, HFRS, medicine.symptom, business |
| الوصف: | Hemorrhagic fever with renal syndrome (HFRS) is an acute viral infectious disease characterized by fever, hemorrhage and renal failure. HFRS has become a serious public health problem in China. Unfortunately, the pathogenesis of HFRS has not been completely clarified. The aim of this study is to investigate the changes of decoy receptor 3 (DcR3) and to further explore its potential roles in HFRS. The levels of serum DcR3 were measured by sandwich ELISA. We found serum DcR3 levels increased significantly, which reached peak value during the oliguric phase and in the critical group. Moreover, serum DcR3 levels were closely related to the levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and parameters reflecting kidney injury including BUN, creatinine (Cr) and proteinuria. This study indicates that high levels of serum DcR3 have associations with the disease stages, severity and degree of kidney damage. Meanwhile, our results suggest that DcR3 may play a dual role in HFRS pathogenesis. First, DcR3 is involved in the inflammatory cascade response resulting in capillary permeability and kidney injury in the early stage. Secondly, HTNV infection induced DcR3 expression at the convalescent phase may act as a feed-back mechanism in anti-inflammatory response. Thus, a study of DcR3 is essential for a better understanding of HFRS pathogenesis. |
| تدمد: | 1970-9366 1828-0447 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ab54031fc2c0d82139fdf6c32b9c99Test https://doi.org/10.1007/s11739-015-1195-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f4ab54031fc2c0d82139fdf6c32b9c99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19709366 18280447 |
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