Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry
| العنوان: | Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry |
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| المؤلفون: | Nunez-Gil I, Fernandez-Perez C, Estrada V, Becerra-Munoz V, El-Battrawy I, Uribarri A, Fernandez-Rozas I, Feltes G, Viana-Llamas M, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Castro-Mejia A, Cerrato E, Astrua T, D'Ascenzo F, Fabregat-Andres O, Moreu J, Guerra F, Signes-Costa J, Marin F, Buosenso D, Bardaji A, Raposeiras-Roubin S, Elola J, Molino A, Gomez-Doblas J, Abumayyaleh M, Aparisi A, Molina M, Guerri A, Arroyo-Espliguero R, Assanelli E, Mapelli M, Garcia-Acuna J, Brindicci G, Manzone E, Ortega-Armas M, Bianco M, Trung C, Nunez M, Castellanos-Lluch C, Garcia-Vazquez E, Cabello-Clotet N, Jamhour-Chelh K, Tellez M, Fernandez-Ortiz A, Macaya C, HOPE COVID-19 Investigators |
| المصدر: | Internal and Emergency Medicine r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Registry, Disease, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Registries, Mortality, Propensity Score, Aged, Framingham Risk Score, business.industry, Mortality rate, Score, Outbreak, COVID-19, Hydroxychloroquine, Middle Aged, medicine.disease, Prognosis, Im - Original, Hospitalization, Survival Rate, Italy, Spain, Propensity score matching, Emergency Medicine, Female, Risk assessment, business, Dyslipidemia, medicine.drug |
| الوصف: | Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients discharged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52–79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I–IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-ORhydroxychloroquine 0.88; 95% CI 0.81–0.91, p = 0.005; adjusted-ORantiviral 0.94; 95% CI 0.87–1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399. Electronic supplementary material The online version of this article (10.1007/s11739-020-02543-5) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| تدمد: | 1970-9366 1828-0447 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d46a00bee201a73608e1b70b5f4f688Test https://pubmed.ncbi.nlm.nih.gov/33165755Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d46a00bee201a73608e1b70b5f4f688 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19709366 18280447 |
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