A Pilot Study of Acupuncture in Treating Bortezomib-Induced Peripheral Neuropathy in Patients With Multiple Myeloma
| العنوان: | A Pilot Study of Acupuncture in Treating Bortezomib-Induced Peripheral Neuropathy in Patients With Multiple Myeloma |
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| المؤلفون: | Michelle Medeiros, Olga Goloubeva, Neil C. Porter, Mariola Sadowska, Lixing Lao, Lisa Hester, Ting Bao, Colleen Pelser, James Primrose, Ashraf Badros, Susan G. Dorsey, Rena G. Lapidus |
| المصدر: | Integrative Cancer Therapies. 13:396-404 |
| بيانات النشر: | SAGE Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Acupuncture Therapy, Antineoplastic Agents, Pilot Projects, Gynecologic oncology, Article, Bortezomib, Internal medicine, Acupuncture, Humans, Medicine, Multiple myeloma, Aged, Pain Measurement, business.industry, Peripheral Nervous System Diseases, Pain scale, Middle Aged, medicine.disease, Boronic Acids, Discontinuation, Surgery, Treatment Outcome, Peripheral neuropathy, Complementary and alternative medicine, Oncology, Pyrazines, Cytokines, Feasibility Studies, Analysis of variance, Multiple Myeloma, business, medicine.drug |
| الوصف: | Background. Peripheral neuropathy is the dose limiting toxicity of bortezomib in patients with multiple myeloma (MM). Objectives. To examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms. Methods. Patients with MM experiencing persistent BIPN ≥grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks (2×/week for 2 weeks, 1×/week for 4 weeks, and then biweekly for 4 weeks). Responses were assessed by the Clinical Total Neuropathy Score (TNSc), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group–Neurotoxicity (FACT/GOG-Ntx) questionnaire, and the Neuropathy Pain Scale (NPS). Repeated-measures analysis of variance was used to test for monotonic decline in scores on each of the measures. Serial serum levels of proinflammatory and neurotrophic cytokines were obtained at baseline and weeks 1, 2, 4, 8, and 14. Results. Twenty-seven patients with MM were enrolled in the trial. There were no adverse events associated with the acupuncture treatments. TNSc data were deemed invalid and therefore were not reported. At weeks 10 and 14, FACT/GOG-Ntx and NPS showed significant reduction suggesting decreased pain, and improved function ( P values were |
| تدمد: | 1552-695X 1534-7354 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038353fa4c6e62f336ab04651c8d8175Test https://doi.org/10.1177/1534735414534729Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....038353fa4c6e62f336ab04651c8d8175 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1552695X 15347354 |
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