دورية أكاديمية
Differential Effects of on Human Glioblastoma Multiforme Cells
| العنوان: | Differential Effects of on Human Glioblastoma Multiforme Cells |
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| المؤلفون: | Li-Jeng Chen MSc, Tsai-Ching Hsu PhD, Pei-Jung Yeh MSc, Jia Le Yow MSc, Chia-Ling Chang BSc, Cheng-Hui Lin MD, Bor-Show Tzang PhD |
| المصدر: | Integrative Cancer Therapies, Vol 20 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Introduction: Glioblastoma multiforme (GBM) is the most aggressive glioma, and its diffuse nature makes resection of it difficult. Moreover, even with the administration of postoperative radiotherapy and chemotherapy, prolonged remission is often not achieved. Hence, innovative or alternative treatments for GBM are urgently required. Traditional Chinese herbs and their functional components have long been used in the treatment of various cancers, including GBM. The current study investigated the antitumor activity of Wedelia chinensis and its major functional components, luteolin and apigenin, on GBM. Materials and Methods: MTT assay, Transwell migration assay, and flow cytometry analysis were adopted to assess the cell viability, invasive capability, and cell cycle. Immunofluorescence staining and Western blotting were used to detect the expressions of apoptotic and autophagy-related signaling molecules. Results: The W. chinensis extract (WCE) significantly inhibited the proliferation and invasive ability of both GBM8401 and U-87MG cells in a dose-dependent manner. Moreover, differential effects of WCE on GBM8401 and U-87MG cells were observed: WCE induced apoptosis in GBM8401 cells and autophagy in U-87MG cells. Notably, WCE had significant effects in reducing the cell survival and invasive capability of both GBM8401 and U-87MG cells than the combination of luteolin and apigenin. Conclusions: Taken together, these findings indicate the potential of using WCE and the combination of luteolin and apigenin for GBM treatment. However, further investigations are warranted before considering recommending the clinical use of WCE or the combination of luteolin and apigenin as the standard for GBM treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1534-7354 1552-695X 15347354 |
| العلاقة: | https://doaj.org/toc/1534-7354Test; https://doaj.org/toc/1552-695XTest |
| DOI: | 10.1177/15347354211000119 |
| الوصول الحر: | https://doaj.org/article/964d9cd6add040058980443d37c26efeTest |
| رقم الانضمام: | edsdoj.964d9cd6add040058980443d37c26efe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15347354 1552695X |
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| DOI: | 10.1177/15347354211000119 |