التفاصيل البيبلوغرافية
| العنوان: |
Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected Pd(II) complexes. |
| المؤلفون: |
Skoczynska, Anna1, Lux, Karin2, Mayer, Peter2, Lorenz, Ingo-Peter2, Krajewska, Urszula3, Rozalski, Marek3, Dołęga, Anna4, Budzisz, Elzbieta1 elzbieta.budzisz@umed.lodz.pl |
| المصدر: |
Inorganica Chimica Acta. Feb2017, Vol. 456, p105-112. 8p. |
| مصطلحات موضوعية: |
*CELL-mediated cytotoxicity, *COUMARINS, *DENSITY functional theory, *LIGANDS (Chemistry), *LIPOPHILICITY |
| مستخلص: |
This paper presents the synthesis of two new ( p -cymene)-ruthenium(II) complexes 3a , b with the bidentate coumarin ligands 2a , b . Both complexes were characterized by FTIR spectroscopy, 1 H NMR, 13 C NMR, MS, elemental analysis and DFT calculations. The X-ray structure of complex 3a was also solved. The cytotoxic properties of both complexes were examined on human leukemia NALM-6 and HL-60 cells and melanoma WM-115 cells. The complexes possess higher cytotoxic activity than the ligands, but distinctive result is for complex 3b , which exhibited higher cytotoxic effect on WM-115 cells (IC 50 = 60.2 ± 7.8 μM) in comparison to carboplatin (IC 50 = 422.2 ± 50.2 μM). The results of DFT calculations performed at the BP86-D3/QZ4P level for Ru(II) complexes and Pd(II) complexes with the same ligands indicate that Pd(II) complexes are more lipophilic. Moreover the RP-TLC-Based Lipophilicity assessment was also performed. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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