Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy
| العنوان: | Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy |
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| المؤلفون: | Fei He, Shouping Zhu, Jie Tian, Bo Hu, Ruichan Lv, Liyang Xiao, Miao Feng, Piaoping Yang |
| المصدر: | Inorganic Chemistry. 57:14594-14602 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Models, Molecular, Lanthanide, Cell Survival, Infrared Rays, medicine.medical_treatment, Metal Nanoparticles, chemistry.chemical_element, Nanoparticle, Antineoplastic Agents, Photodynamic therapy, 02 engineering and technology, Crystallography, X-Ray, 010402 general chemistry, Photochemistry, 01 natural sciences, Inorganic Chemistry, Erbium, Mice, medicine, Animals, Humans, Photosensitizer, Physical and Theoretical Chemistry, Cell Proliferation, Photosensitizing Agents, Quenching (fluorescence), Molecular Structure, Optical Imaging, Doping, Mammary Neoplasms, Experimental, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Photochemotherapy, chemistry, MCF-7 Cells, Drug Screening Assays, Antitumor, 0210 nano-technology, Luminescence |
| الوصف: | Generally, luminescence quenching at high doping concentrations typically limits the concentration of doped ions in the lanthanide material to less than 0.05-20 mol %, and this is still a major hindrance in designing nanoplatforms with improved brightness. In this research, a nanoplatform capable of dual-modal imaging and synergetic antitumor cells therapy was designed. NaYF4: x%Er@NaXF4 ( x = 5, 25, 50, and 100; X = Lu and Y) core@shell nanoparticles with Er3+ ion concentration up to 100 mol % were synthesized, and the luminescence properties under near-infrared (NIR) excitation were detected. The results show the strong coupled of surface and concentration quenching effects in upconversion nanoparticles (UCNP). Upconversion luminescence (UCL) and NIR-II emission intensity increased with negligible concentration quenching effect under 980 and 800 nm NIR lasers because of the growth of epitaxial shells. Therefore, the enhanced red luminescence transfers energy to photosensitizer ZnPc as the photodynamic therapy (PDT) agent for tumor inhibition efficacy. |
| تدمد: | 1520-510X 0020-1669 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648b7b47661059cb14369c78ae7ec109Test https://doi.org/10.1021/acs.inorgchem.8b02257Test |
| رقم الانضمام: | edsair.doi.dedup.....648b7b47661059cb14369c78ae7ec109 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520510X 00201669 |
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