التفاصيل البيبلوغرافية
| العنوان: |
Subacute inhalation toxicity study of synthetic amorphous silica nanoparticles in Sprague-Dawley rats. |
| المؤلفون: |
Shin, Jae Hoon, Jeon, KiSoo, Kim, Jin Kwon, Kim, Younghun, Jo, Mi Seong, Lee, Jong Seong, Baek, Jin Ee, Park, Hye Seon, An, Hyo Jin, Park, Jung Duck, Ahn, Kangho, Oh, Seung Min, Yu, Il Je |
| المصدر: |
Inhalation Toxicology; Oct-Dec2017, Vol. 29 Issue 12-14, p567-576, 10p |
| مصطلحات موضوعية: |
SILICA nanoparticles, TOXICOLOGY of poisonous gases, BRONCHOALVEOLAR lavage, NEUTROPHILS, ENVIRONMENTAL exposure |
| مستخلص: |
Synthetic amorphous silica nanoparticles (SiNPs) are one of the most applied nanomaterials and are widely used in a broad variety of industrial and biomedical fields. However, no recent long-term inhalation studies evaluating the toxicity of SiNPs are available and results of acute studies are limited. Thus, we conducted a subacute inhalation toxicity study of SiNPs in Sprague-Dawley rats using a nose-only inhalation system. Rats were separated into four groups and target concentrations selected in this study were as follows: control (fresh air), low- (0.407 ± 0.066 mg/m3), middle- (1.439 ± 0.177 mg/m3) and high-concentration group (5.386 ± 0.729 mg/m3), respectively. The rats were exposed to SiNPs for four consecutive weeks (6 hr/day, 5 days/week) except for control group of rats which received filtered fresh air. After 28-days of inhalation exposure to SiNPs, rats were sacrificed after recovery periods of one, seven and 28 days. Although there were minimal toxic changes such as temporary decrease of body weight after exposure, increased levels of red blood cells (RBCs) and hemoglobin (Hb) concentration, the lung histopathological findings and inflammatory markers in bronchoalveolar lavage (BAL) fluid including polymorphonuclear (PMN) leukocyte, lactate dehydrogenase (LDH), albumin and protein did not show significant changes at any recovery period. The results of this study suggest that the subacute inhalation of SiNPs had no toxic effects on the lung of rats at the concentrations and selected time points used in this study. [ABSTRACT FROM AUTHOR] |
|
Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
