التفاصيل البيبلوغرافية
| العنوان: |
Toxicity of boehmite nanoparticles: impact of the ultrafine fraction and of the agglomerates size on cytotoxicity and pro-inflammatory response. |
| المؤلفون: |
Forest, Valérie, Pailleux, Mélanie, Pourchez, Jérémie, Boudard, Delphine, Tomatis, Maura, Fubini, Bice, Sennour, Mohamed, Hochepied, Jean-François, Grosseau, Philippe, Cottier, Michèle |
| المصدر: |
Inhalation Toxicology; Aug2014, Vol. 26 Issue 9, p545-553, 9p |
| مصطلحات موضوعية: |
BOEHMITE, NANOPARTICLES, OXIDATIVE stress, MACROPHAGES, TOXICITY testing |
| مستخلص: |
Boehmite (γ-AlOOH) nanoparticles (NPs) are used in a wide range of industrial applications. However, little is known about their potential toxicity. This study aimed at a better understanding of the relationship between the physico-chemical properties of these NPs and their in vitro biological activity. After an extensive physico-chemical characterization, the cytotoxicity, pro-inflammatory response and oxidative stress induced by a bulk industrial powder and its ultrafine fraction were assessed using RAW264.7 macrophages. Although the bulk powder did not trigger a significant biological activity, pro-inflammatory response was highly enhanced with the ultrafine fraction. This observation was confirmed with boehmite NPs synthesized at the laboratory scale, with well-defined and tightly controlled physico-chemical features: toxicity was increased when NPs were dispersed. In conclusion, the agglomerates size of boehmite NPs has a major impact on their toxicity, highlighting the need to study not only raw industrial powders containing NPs but also the ultrafine fractions representative of respirable particles. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
