التفاصيل البيبلوغرافية
| العنوان: |
Inflammation inhibits GPR81 expression in adipose tissue. |
| المؤلفون: |
Feingold, Kenneth R., Moser, Arthur, Shigenaga, Judy K., Grunfeld, Carl |
| المصدر: |
Inflammation Research; Oct2011, Vol. 60 Issue 10, p991-995, 5p |
| مصطلحات موضوعية: |
ADIPOSE tissue physiology, INFLAMMATION, G protein coupled receptors, PROTEIN expression, THERAPEUTIC use of cytokines |
| مستخلص: |
Objective and design: The aim of this study was to examine the expression of G protein-coupled receptor 81 (GPR81) in mouse adipose tissue in response to inflammatory stimuli. GPR81 is activated by lactate resulting in the inhibition of lipolysis. Materials and treatment: Mice were injected with saline, lipopolysaccharide (LPS), zymosan, or turpentine, N = 5 per group. 3T3-L1 adipocytes were treated with tumor necrosis factor alpha, interleukin (IL)-l beta, IL-6, or interferon gamma. Methods: GPR81 expression levels were measured by real-time PCR and statistical significance was determined by Student's t test. Results: LPS resulted in a marked decrease in GPR81 mRNA level in mouse adipose tissue in C57BL/6 and OuJ mice, an effect that was not observed in HeJ mice, which have a mutation in TLR4. Zymosan and turpentine also decreased adipose tissue GPR81expression. Cytokine treatment of 3T3-L1 adipocytes had no effect on GPR81 expression. GPR81 expression was decreased in ob/ob mice, an animal model of type 2 diabetes that is characterized by inflammation. Conclusion: Inflammation decreases the expression of GPR81 in adipose tissue. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
