التفاصيل البيبلوغرافية
| العنوان: |
The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture. |
| المؤلفون: |
Jacobs, Cale A., Olsen, Zachary M., Marchand, Lucas S., Kraus, Virginia B., Anderson, Donald D., Haller, Justin |
| المصدر: |
Inflammation Research; Jan2023, Vol. 72 Issue 1, p9-11, 3p |
| مصطلحات موضوعية: |
INFLAMMATION, SYNOVIAL fluid, ANKLE fractures, CLUSTER analysis (Statistics), TIBIAL plateau fractures, MATRIX metalloproteinases, OSTEOARTHRITIS |
| مستخلص: |
Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
