Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment
| العنوان: | Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment |
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| المؤلفون: | Wolfgang Henke, Ingolf Schimke, Werner Siems, Klaus Jung, A. Haberland, Tilman Grune |
| المصدر: | Europe PubMed Central |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Immunology, Kidney, medicine.disease_cause, Nephrotoxicity, Superoxide dismutase, chemistry.chemical_compound, Superoxides, Internal medicine, medicine, Animals, Rats, Wistar, Pharmacology, Heart transplantation, Glutathione Disulfide, biology, Superoxide Dismutase, Chemistry, Myocardium, Heart, Metabolism, Glutathione, Rats, Transplantation, Oxidative Stress, Endocrinology, medicine.anatomical_structure, Liver, Cyclosporine, biology.protein, Lipid Peroxidation, Immunosuppressive Agents, Oxidative stress |
| الوصف: | Objective and Design: The study was designed to elucidate whether cyclosporine A (Cy A) induces oxidative stress in heart, liver and kidney.¶Material and Treatment: Male Wistar rats were treated with NaCl (n = 7), cremophor (vehicle for Cy A; n = 7) and 30 mg/kg b.w. Cy A in cremophor (n = 7) daily for 4 weeks.¶Methods: Oxidized (GSSG) and reduced (GSH) glutathione, lipid peroxides and superoxide dismutase were measured in the organs.¶Results: Increases in GSSG [nmol/mg prot.] and a compensatory rise in total GSH [nmol/mg prot.] indicating Cy A-induced oxidative stress were found in kidney (0.39 ± 0.09 vs. 0.47 ± 0.14 vs. 0.64 ± 0.18; 20.71 ± 3.86 vs. 21.07 ± 3.86 vs. 28.14 ± 3.37) and liver (0.51 ± 0.11 vs. 0.51 ± 0.09 vs. 0.65 ± 0.25; 33.35 ± 5.06 vs. 32.88 ± 5.12 vs. 44.12 ± 6.06) but not in heart.¶Conclusion: Cy A-induced oxidative stress may contribute to the hepatotoxicity and nephrotoxicity of this drug. After heart transplantation, accelerated allograft atherosclerosis limits transplantation success. We did not find any evidence that Cy A induces oxidative stress in the heart which might favour atherogenesis. |
| تدمد: | 1420-908X 1023-3830 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81af93653b6e88ed6410f4c93f2fdc00Test https://doi.org/10.1007/s000110050223Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....81af93653b6e88ed6410f4c93f2fdc00 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1420908X 10233830 |
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