Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications
| العنوان: | Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications |
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| المؤلفون: | Dorota Zozulińska-Ziółkiewicz, Maria Pioruńska-Stolzmann, Małgorzata Wegner, Aleksandra Araszkiewicz, Bogna Wierusz-Wysocka |
| المصدر: | Inflammation |
| بيانات النشر: | Springer US, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | musculoskeletal diseases, microvascular complications, Adult, Blood Glucose, Male, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, type 1 diabetes, Immunology, interleukin 6, Diabetic angiopathy, Article, Body Mass Index, chemistry.chemical_compound, BMI, Internal medicine, Diabetes mellitus, Immunology and Allergy, Medicine, Humans, Interleukin 6, Triglycerides, Inflammation, Type 1 diabetes, medicine.diagnostic_test, biology, business.industry, Cholesterol, Interleukin-6, Cholesterol, HDL, Cholesterol, LDL, medicine.disease, Rheumatology, lipid profile, Endocrinology, Diabetes Mellitus, Type 1, chemistry, biology.protein, Female, business, Lipid profile, Body mass index, Diabetic Angiopathies |
| الوصف: | Interleukin 6 (IL-6) plays an important role in the initiation and acceleration of chronic inflammation and could contribute to development of microvascular complications in patients with type 1 diabetes (DM1). Therefore, this study was aimed to investigate the association between concentration of IL-6 in relation to glucose control, lipid profile, and body mass index (BMI) in 69 DM1 patients subdivided according to the absence or presence of microvascular complications. BMI, level of fasting plasma glucose (FPG), and concentrations of total cholesterol (TCH), LDL cholesterol (LDL-C), and IL-6 were higher in DM1 patients compared to the control group. In DM1 patients, IL-6 concentration was positively correlated with level of FPG, LDL-C, TCH concentrations, and BMI. These correlations were stronger in the subgroup of patients with microvascular complications. In addition, BMI independently influences IL-6 concentration in DM1 patients. In conclusion, elevated IL-6 concentration is associated with diabetes-related variables which could accelerate progression of microvascular complications in DM1 patients. |
| اللغة: | English |
| تدمد: | 1573-2576 0360-3997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4697c2d7660eda08eba08d0ce91d6cacTest http://europepmc.org/articles/PMC3648680Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4697c2d7660eda08eba08d0ce91d6cac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732576 03603997 |
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