Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China, 2017
| العنوان: | Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China, 2017 |
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| المؤلفون: | Lin Xiao, Xiao-Guang Sun, Lin Chen, Ling-Jie Liao, Xiaoqin Xu, Hui Xing, Shui-Bin Luo, Hongyan Lu, Ruihua Kang, Guohui Wu, Yanling Ma, Shujia Liang, Shu Liang, Jianmei He, Yiming Shao, Yuhua Ruan, Xin-Hui Zhang |
| المصدر: | Infectious Diseases of Poverty Infectious Diseases of Poverty, Vol 9, Iss 1, Pp 1-9 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, China, Anti-HIV Agents, 030106 microbiology, Human immunodeficiency virus (HIV), Pretreatment drug resistance, HIV Infections, Drug resistance, Logistic regression, medicine.disease_cause, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Drug Resistance, Viral, Prevalence, Medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, Transmission network, Aged, Aged, 80 and over, business.industry, Transmission (medicine), lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, HIV, lcsh:RA1-1270, General Medicine, Odds ratio, Middle Aged, Antiretroviral therapy, Infectious Diseases, Cross-Sectional Studies, Tropical medicine, Female, business, HIV drug resistance, Research Article |
| الوصف: | BackgroundAfter the scale-up of antiretroviral therapy (ART) for HIV infected people, increasing numbers of patients have pretreatment drug resistance (PDR). In this study, the prevalence of PDR was evaluated in adults initiating antiretroviral therapy in China.MethodsBlood samples were obtained from 1943 patients who initiated antiretroviral therapy (ART) in 2017 from 13 provinces or cities in China. Pol sequences were used to analyze drug resistance and construct transmission networks. Logistic regression model was used to estimate the potential factors associated with PDR.ResultsIn total, 1711 eligible patients (76.0% male; 87.8% aged ≥ 25 years) were included, of which 117 (6.8%) had PDR. The highest rates of PDR were 12.2% in Liangshan Prefecture of Sichuan and 9.3 and 8.9% in Dehong and Lincang Prefecture of Yunnan. A multivariate logistic regression analysis revealed that PDR was significantly higher among intravenous drug users (adjusted Odds Ratio (aOR) = 2.64, 95%CI: 1.57–4.44) and individuals from Liangshan, Dehong, and Lincang (aOR = 2.04, 95%CI: 1.26–3.30). In total, 754 sequences were used to generate 164 transmission networks. Five transmission networks had two or three sequences containing the same mutations, two networks contained subjects from Liangshan, and one network contained subjects from Dehong.ConclusionsOverall, the PDR prevalence was moderate, with a particularly high prevalence in areas with severe HIV epidemics. These results indicate the importance of continuous PDR monitoring in patients initiating antiretroviral therapy. |
| اللغة: | English |
| تدمد: | 2049-9957 2095-5162 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d76933cba682e00810e865e18b42afTest http://europepmc.org/articles/PMC7247188Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8d76933cba682e00810e865e18b42af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20499957 20955162 |
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