Effectiveness and Safety of Micafungin in Managing Invasive Fungal Infections among Patients in Greece with Hematologic Disorders: The ASPIRE Study
| العنوان: | Effectiveness and Safety of Micafungin in Managing Invasive Fungal Infections among Patients in Greece with Hematologic Disorders: The ASPIRE Study |
|---|---|
| المؤلفون: | Marina Moustaka, Christina Papadaki, George Vassilopoulos, Vasiliki Pappa, Maria Kotsopoulou, Ioannis Baltadakis, Manto Tzanetakou, Konstantinos Anargyrou, Kleoniki Liakou, Maria K. Angelopoulou, Helen A. Papadaki, Alexandros Spyridonidis |
| المصدر: | Infectious Diseases and Therapy, Vol 8, Iss 2, Pp 255-268 (2019) Infectious Diseases and Therapy |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, 030106 microbiology, Hematopoietic stem cell transplantation, Antifungal, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Hematologic disorders, Internal medicine, Medicine, lcsh:RC109-216, 030212 general & internal medicine, Prospective cohort study, Adverse effect, Original Research, Prophylaxis, business.industry, Micafungin, Cancer, medicine.disease, 3. Good health, Discontinuation, Invasive candidiasis, Infectious Diseases, Hematologic disease, HSCT, business, medicine.drug |
| الوصف: | Introduction Invasive candidiasis (IC) can be a life-threatening infection in immunocompromised patients, particularly those with cancer, hematologic diseases and/or hematopoietic stem cell transplantation (HSCT) recipients. The objective of this study was to evaluate the effectiveness of micafungin in patients with hematologic malignancies or HSCT recipients, relevant to clinical presentation of IC, in real-life practice in Greece. Methods ASPIRE was a phase IV, multicenter, non-interventional, prospective cohort study, conducted at ten tertiary hospitals in Greece, in adults with hematologic disease. Micafungin treatment for IC or prophylaxis for Candida infection was administered per standard clinical practice until a clinical outcome (success or failure) was reached. Treatment success was defined by the EORTC/MSG criteria for invasive fungal infections (IFI) and was assessed by the investigator. Treatment discontinuation and safety were also evaluated. Results One hundred forty-three patients were enrolled. Median age was 62; 85 (59.4%) patients were male, and 133 (93.0%) had Greek ethnicity. One hundred twenty-six (88.1%) patients had hematologic malignancies, and 21 (14.7%) had received HSCT. Prophylaxis was administered to 74 (51.7%) patients [median (range) dose: 50 (50–150) mg/day] with no signs of IFI. Overall, 52 (36.4%) patients with possible IFI at baseline received micafungin treatment [100 (50–125) mg/day] versus 12 (17.2%) with probable [100 (75–150) mg/day] and 5 (3.5%) with confirmed [125 (100–150) mg/day] IFI. Treatment success was 91.6% (95% CI 85.80–95.59; n = 131) overall and 90.5% (n = 67) in patients receiving prophylaxis. Median time on treatment was 13 days. Treatment discontinuation (n = 26; 18.2%) was not related to adverse events. No treatment-related serious adverse events were reported. Conclusion Micafungin treatment for IC or prophylaxis for Candida infection was effective and well tolerated in patients with hematologic disorders in clinical practice in Greece. These results demonstrate that micafungin could be used more widely for prophylaxis. Further work is required to determine the efficacy and safety of micafungin for the management of IFIs in hematologic settings. Funding Astellas Pharma Inc. |
| تدمد: | 2193-6382 2193-8229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef6ee26913f8e1a551b0a5eb3266a3dTest https://doi.org/10.1007/s40121-019-0236-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ef6ee26913f8e1a551b0a5eb3266a3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21936382 21938229 |
|---|