In vivo activation of neutrophil function in hamsters by recombinant human granulocyte colony-stimulating factor
| العنوان: | In vivo activation of neutrophil function in hamsters by recombinant human granulocyte colony-stimulating factor |
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| المؤلفون: | B J Ratzkin, D K Hines, A M Cohen, E S Korach |
| المصدر: | Infection and Immunity. 56:2861-2865 |
| بيانات النشر: | American Society for Microbiology, 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | Staphylococcus aureus, Neutrophils, medicine.medical_treatment, Immunology, Intraperitoneal injection, Hamster, Biology, Granulocyte, Microbiology, Leukocyte Count, chemistry.chemical_compound, Subcutaneous injection, Colony-Stimulating Factors, Phagocytosis, Superoxides, In vivo, Cricetinae, Granulocyte Colony-Stimulating Factor, medicine, Animals, Staphylococcal Infections, N-Formylmethionine leucyl-phenylalanine, Colony-stimulating factor, Recombinant Proteins, Granulocyte colony-stimulating factor, N-Formylmethionine Leucyl-Phenylalanine, Infectious Diseases, medicine.anatomical_structure, chemistry, Parasitology, Research Article |
| الوصف: | The in vivo effect of Escherichia coli-derived recombinant human granulocyte colony-stimulating factor on neutrophil function was studied in golden Syrian hamsters. Significant increases in superoxide generation and specific binding of N-formylmethionyl-leucyl-phenylalanine were observed in neutrophils isolated 4 h following a single subcutaneous injection of the factor (30 micrograms/kg). However, phagocytotic activity was not significantly stimulated in hamsters treated with the factor. Recombinant human granulocyte colony-stimulating factor hastened the recovery of peripheral neutrophil counts in animals made leukopenic by prior treatment with cyclophosphamide. Beginning several hours after infection, resistance to lethal infection following intraperitoneal injection of Staphylococcus aureus was increased when neutropenic animals were treated daily with the factor. This protective effect was associated with increased peritoneal neutrophil counts and a decreased incidence of positive peritoneal bacterial cultures at 24 h after the start of treatment. These results suggest that recombinant human granulocyte colony-stimulating factor may be a useful adjunct in the treatment of bacterial infections in neutropenic patients. |
| تدمد: | 1098-5522 0019-9567 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414ed955ad563e12cdb4083380182423Test https://doi.org/10.1128/iai.56.11.2861-2865.1988Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....414ed955ad563e12cdb4083380182423 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985522 00199567 |
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