Synthesis, Radiochemical Purity Control and Stability of Scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA)
| العنوان: | Synthesis, Radiochemical Purity Control and Stability of Scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA) |
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| المؤلفون: | Asri Nurul Bashiroh, Iwan Hastiawan, Duyeh Setiawan |
| المصدر: | Indonesian Journal of Chemistry. 18:153 |
| بيانات النشر: | Universitas Gadjah Mada, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Radionuclide, Ligand, Radiochemistry, chemistry.chemical_element, General Chemistry, 010501 environmental sciences, 010403 inorganic & nuclear chemistry, 01 natural sciences, Beta decay, 0104 chemical sciences, Paper chromatography, chemistry, Scandium, Stoichiometry, 0105 earth and related environmental sciences |
| الوصف: | Radiotherapy is one of healing method of cancer using radionuclide elements. The radionuclide scandium-46 (46Sc) has a half-life of 83.8 days, beta emission 0.35 MeV and gamma emission 899 and 1120 keV is suitable for studying the chemical aspects, synthesis and stability of scandium complex for radiotherapy. The purposes of this research are synthesis of scandium-46-1,4,7-triazacyclononane-1,4,7-triacetic acid (46Sc-NOTA) labeled compound based on formation of a complex bonding in stoichiometry between radioisotope 46Sc and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) ligand, and radiochemical purity and stability assay of 46Sc-NOTA. In this research, conducted that optimum moles several variables, namely moles comparison and pH effect was used. The result are optimum conclusion of mole comparison between radioisotope and ligand was 1:2 (46Sc : NOTA) and environment at pH 5. The radiochemical purity and stability assay of 46Sc-NOTA was carried out by paper chromatography and the result showed that 46Sc-NOTA has radiochemical purity of 99.09 ± 0.2% and remained stable for 9 days. |
| تدمد: | 2460-1578 1411-9420 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::78f3449c482c85b7922b9aa9cf9fa76dTest https://doi.org/10.22146/ijc.24467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........78f3449c482c85b7922b9aa9cf9fa76d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24601578 14119420 |
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