New Antihistaminic Agents: Synthesis and Evaluation of H1-Antihistaminic actions of 3-[(N,N-Dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1H)-thioquinazolin-4(3H)-ones and Their oxo Analogues.

التفاصيل البيبلوغرافية
العنوان:	New Antihistaminic Agents: Synthesis and Evaluation of H1-Antihistaminic actions of 3-[(N,N-Dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1H)-thioquinazolin-4(3H)-ones and Their oxo Analogues.
المؤلفون:	Raju, M. B.¹, Singh, S. D.¹, Rao, A. Raghu Ram² raghumed@hotmail.com, Rajan, K. S.²
المصدر:	Indian Journal of Pharmaceutical Sciences. 2007, Vol. 69 Issue 6, p853-856. 4p. 1 Diagram, 2 Charts.
مصطلحات موضوعية:	ANTIHISTAMINES, ANTIALLERGIC agents, IMMUNOPHARMACOLOGY, CLINICAL drug trials, *PHARMACOLOGY
مستخلص:	The synthesis of eight new 3-[(N,N-dialkylamino)allkyl]-2(1H)-thioquinazolin-4(3H)-ones (3a-d) and their oxo analogues (4a-d) has been described. H1-Antihistaminic activities have been evaluated using in vitro and in vivo standard animal models in comparison to chlorpheniramine maleate as reference drug. Among the test compounds, 3d was found to be the most potent with an IC50 value of 1.23 µM (in vitro) offering 70.24% protection in vivo. [ABSTRACT FROM AUTHOR]
قاعدة البيانات:	Academic Search Index

الوصف
تدمد:	0250474X