التفاصيل البيبلوغرافية
| العنوان: |
MS: a localized immune disease of the central nervous system |
| المؤلفون: |
C. M. Watson, Marc Feldmann, Alan N. Davison, Samantha Owen, Virginia L. Calder |
| المصدر: |
Immunology today. 10(3) |
| سنة النشر: |
1989 |
| مصطلحات موضوعية: |
Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, biology, business.industry, Encephalomyelitis, Multiple sclerosis, T-Lymphocytes, Immunology, Central nervous system, Myelin Basic Protein, Disease, medicine.disease, Myelin basic protein, medicine.anatomical_structure, Animal model, Immune system, Antigen, medicine, biology.protein, Humans, business, Demyelinating Diseases |
| الوصف: |
The precise role of T cells in multiple sclerosis (MS) remains to be defined. No MS-specific antigen has been found. The autoimmune hypothesis for MS rests on immune changes seen in the spinal fluid and brain and on the demonstration, in an experimental animal model, that T cells raised to myelin basic protein transfer demyelination. In this review, Virginia Calder and colleagues focus on recent studies suggesting that in MS, the initial T-cell response occurs within the central nervous system and that the blood poorly reflects this immune activity. This contrasts with the animal model, experimental allergic encephalomyelitis, where the initial immune response is peripheral. © 1989. |
| تدمد: |
0167-5699 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e984ce76377efe98bf852af0ff7a5a40Test
https://pubmed.ncbi.nlm.nih.gov/2472812Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....e984ce76377efe98bf852af0ff7a5a40 |
| قاعدة البيانات: |
OpenAIRE |
