دورية أكاديمية
Hypothesis: Biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation
| العنوان: | Hypothesis: Biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation |
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| المؤلفون: | Franklin, Andrew, Blanden, Robert |
| المصدر: | Immunology and Cell Biology |
| بيانات النشر: | Blackwell Publishing Ltd |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: cytidine deaminase, matrix attachment region binding protein, article, B lymphocyte, DNA supercoiling, gene locus, genetic strain, intron, molecular mechanics, nonhuman, somatic hypermutation, transgenic mouse, Antigens, B-Lymphocytes, Gene Rearrangement, Affinity maturation, Class switch recombination, DNA remodelling, Matrix attachment region |
| الوصف: | A major function of J-C intronic matrix attachment regions (MAR) during immune diversification via somatic hypermutation (SHM) at immunoglobulin loci may be to manipulate the topology of DNA within the upstream target domain. The suggestion that SHM induction requires MAR-induced torsional strain, in conjunction with DNA remodelling at the J-C intron, completes the definition of a cogent paradigm within which all extant molecular data on the issue may be interpreted. Moreover, the suggestion that a mutagenic mechanism relieves MAR-generated superhelicity could provide an indication as to the evolutionary basis of SHM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0818-9641 |
| العلاقة: | http://hdl.handle.net/1885/78774Test; https://openresearch-repository.anu.edu.au/bitstream/1885/78774/5/01_Franklin_Hypothesis%3A_Biological_role_2005.pdf.jpgTest |
| DOI: | 10.1111/j.1440-1711.2005.01327.x |
| الإتاحة: | https://doi.org/10.1111/j.1440-1711.2005.01327.xTest http://hdl.handle.net/1885/78774Test https://openresearch-repository.anu.edu.au/bitstream/1885/78774/5/01_Franklin_Hypothesis%3A_Biological_role_2005.pdf.jpgTest |
| رقم الانضمام: | edsbas.75B20C1F |
| قاعدة البيانات: | BASE |
| تدمد: | 08189641 |
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| DOI: | 10.1111/j.1440-1711.2005.01327.x |