Tissue‐resident regulatory T cells accumulate at human barrier lymphoid organs
| العنوان: | Tissue‐resident regulatory T cells accumulate at human barrier lymphoid organs |
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| المؤلفون: | Frederic Sierro, Umaimainthan Palendira, Asolina Braun, Angela Ferguson, Tomoki Ohashi, Thomas S. Watkins, Carl G. Feng, Georgia Gasparini, John J. Miles, Warwick J. Britton, Rehana Hewavisenti, Stuart G. Tangye, Thomas Gebhardt, Michael Elliott |
| المصدر: | Immunology & Cell Biology. 99:894-906 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | B-Lymphocytes, Lymphocyte, T cell, Immunology, Peripheral tolerance, hemic and immune systems, chemical and pharmacologic phenomena, Spleen, Cell Biology, Biology, Lymphocyte Activation, T-Lymphocytes, Regulatory, Phenotype, Mice, medicine.anatomical_structure, Lymphatic system, medicine, Animals, Humans, Immunology and Allergy, Homeostasis, B cell |
| الوصف: | Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have been identified in both mice and humans, much of our understanding about how these cells maintain immune homeostasis is derived from animal models. In this study, we examined two distinct human lymphoid organs to understand how repeated exposure to infections at the mucosal surface influences the phenotype and tissue localization of Tregs. We show that while Tregs in both tonsils and spleen express a tissue-resident phenotype, they accumulate in greater numbers in tonsils. Tonsillar-resident Tregs exhibit a highly suppressive phenotype with significantly increased expression of CD39, ICOS and CTLA-4 compared with their counterparts in circulation or in the spleen. Functionally, resident Tregs are able effectively to suppress T cell proliferation. We further demonstrate that tonsillar-resident Tregs share key features of T follicular helper cells. Spatial analysis reveals that the vast majority of resident Tregs are localized at the border of the T-zone and B cell follicle, as well as within the lymphocyte pockets enriched with resident memory T cells. Together our findings suggest that resident Tregs are strategically co-localized to maintain immune homeostasis at sites of recurrent inflammation. |
| تدمد: | 1440-1711 0818-9641 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e517f82084e0572f5f6651e2ce92538Test https://doi.org/10.1111/imcb.12481Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4e517f82084e0572f5f6651e2ce92538 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401711 08189641 |
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