التفاصيل البيبلوغرافية
| العنوان: |
Expression of L-selectin (CD62L) discriminates Th1- and Th2-like cytokine-producing memory CD4+ T cells. |
| المؤلفون: |
Kanegane, H., Kasahara, Y., Niida, Y., Yachie, A., Sugii, S., Takatsu, K., Taniguchi, N., Miyawaki, T. |
| المصدر: |
Immunology; Feb96, Vol. 87 Issue 2, p186-190, 5p |
| مصطلحات موضوعية: |
SELECTINS, TH1 cells, TH2 cells, T cells, CYTOKINES, IMMUNOGLOBULINS |
| مستخلص: |
Human memory (CD45RO+) CD4+ T cells can be distinguished into two subpopulations on the basis of expression of the lymph node homing receptor, L-selectin (CD62L). In a prior study we showed that human L-selectin-positive memory T-helper (Th)cells promote the maturation of IgG- and IgA-producing cells by naive B cells. To further elucidate the contribution of memory CD4+ T cells to B-cell differentiation, human memory CD4+ T cells with or without L-Selectin expression were evaluated for production of cytokines that participate in regulation of immunoglobulin production. It was found that L-selectin-positive human memory CD4+ T cells produce mainly interleukin (IL)-4 and IL-5, whereas L-selectin-negative CD4+ T cells produce mainly interferon-γ (IFN-γ). This profile of cytokine expression coincides with the profile that distinguishes Th1 and Th2 subsets, in contrast to the routine system, IL-10 production was similarly contributed by human L-selectin-positive and -negative memory CD4+ T-cell subpopulations. These results suggest that the human L-selectin-negative and -positive subpopulations of human memory CD4+ T cells contain Th1-like and Th2-like cytokine- producing cells, respectively. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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