التفاصيل البيبلوغرافية
| العنوان: |
Reduction of spontaneous autoimmune diabetes in diabetes-prone BB rats with the novel immunosuppressant fusidic acid. Effect on T-cell proliferation and production of interferon-γ. |
| المؤلفون: |
Nicoletti, F., Di Marco, R., Morrone, S., Zaccone, P., Lembo, D., Grasso, S., Santoni, A., Meroni, P.L., Bendtzen, K. |
| المصدر: |
Immunology; Feb94, Vol. 81 Issue 2, p317-321, 5p |
| مصطلحات موضوعية: |
AUTOIMMUNE diseases, DIABETES, IMMUNOSUPPRESSIVE agents, T cells, CELL proliferation, INTERFERONS |
| مستخلص: |
Diabetes-prone (DP) BB rats spontaneously develop a hyperglycaemic condition which closely resembles human insulin-dependent diabetes mellitus (IDDM), both in terms of clinical and histological features. The incidence of IDDM was significantly reduced when these animals were treated with 2 or 4 mg fusidic acid (FA)/day i.m. from day 30 to day 120 of age. In addition, the mean insulitis score was significantly diminished in the animals treated with FA compared to both vehicletreated and untreated controls. Finally, 2 mg/day of FA i.m. prevented cell proliferation and interferon-γ secretion from peripheral blood mononuclear cells upon ex vivo stimulation with concanavalin A. The capacity of FA to substantially reduce the incidence of autoimmune diabetes in a well-known animal model of human IDDM supports previous observations regarding the immunosuppressive properties of FA and its potential use in the treatment of human autoimmune diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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