التفاصيل البيبلوغرافية
| العنوان: |
Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: a paradigm of host-pathogen adaptation. |
| المؤلفون: |
Lopez-Botet, Miguel, Llano, Manuel, Ortega, Mara |
| المصدر: |
Immunological Reviews. Jun2001, Vol. 181 Issue 1, p193. 10p. |
| مصطلحات موضوعية: |
*IMMUNE response, *VIRUSES, *T cells, *KILLER cells |
| مستخلص: |
Among various strategies to evade the host immune response, some viruses like human cytomegalovirus (HCMV) interfere with surface MHC class I expression and antigen presentation to T lymphocytes. The ability of natural killer (NK) cells to detect MHC class I molecules through inhibitory receptors can be envisaged as an adaptation of the immune system for responding to such pathological alterations. To fulfill that role, rodents use members of the Ly49 C-type lectin superfamily, whereas primated employ killer immunoglobulin-like receptors and the immunoglobulin-like transcript 2/leucocyte immunoglobulin-like receptor-1 receptor. CD94/NKG2 lectin-like heterodimers represent the most conserved receptor system for MHC class I molecules; by interacting with human HLA-E or murine Qa-1b, CD94/NKG2A inhibitory receptors broadly probe the biosynthesis pathway of other class I molecules. Reciprocally, HCMV has developed mechanisms to evade the NK response while modulating HLA class Ia expression. The ability of HCMV to maintain surface levels of HLA-E and to express an HLA class I surrogage (UL18) are herein discussed in the context of the interplay with human NKR systems. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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