The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population
| العنوان: | The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population |
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| المؤلفون: | Khaled A. Alswat, Mohammed Al Dubayee, Amre Nasr, Gamal Allam, Iman M. Talaat, Adnan A. Alsulaimani, Imad Mohamed |
| المصدر: | Immunological Investigations. 47:521-533 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Genotype, Immunology, Population, Saudi Arabia, Polymorphism, Single Nucleotide, Gastroenterology, Pathogenesis, 03 medical and health sciences, Gene Frequency, Risk Factors, Polymorphism (computer science), Internal medicine, Odds Ratio, Humans, Medicine, Genetic Predisposition to Disease, education, Alleles, Genetic Association Studies, Glycated Hemoglobin, education.field_of_study, Type 1 diabetes, C-Peptide, business.industry, Protein Tyrosine Phosphatase, Non-Receptor Type 22, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Logistic Models, 030104 developmental biology, Case-Control Studies, Cohort, Female, Gene polymorphism, business, Biomarkers |
| الوصف: | Recent investigations have reported an association between protein tyrosine phosphatase non-receptor type-22 (PTPN-22) gene polymorphism and susceptibility to the development of type 1 diabetes (T1D) in some populations and not in others. In this study, we aimed to investigate the association of PTPN-22 C1858T polymorphism with T1D in Saudi children.A cohort of 372 type 1 diabetic children and 372 diabetes-free subjects was enrolled in the current investigation. The PTPN-22 C1858T polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Our data showed that the frequency of CT and TT genotypes of PTPN-22 C1858T was higher in T1D children (17.7% and 4.3%, respectively) compared to healthy controls (4.8% and 1.6%, respectively), and both genotypes were statistically associated with T1D patients (OR = 4.4, 95% CI: 2.55-7.58, p 0.001; and OR = 3.2, 95% CI: 1.23-8.28, p = 0.017, respectively). Moreover, the 1858T allele was significantly associated with T1D patients compared to the C allele (OR = 3.2, 95% CI: 1.59-6.88, p 0.001). In addition, the T allele was significantly associated with elevated levels of HbA1c, anti-GAD, and anti-insulin antibodies (p 0.001) and a lower concentration of C-peptide (p 0.001) in T1D children.The data presented here suggests that the T allele of PTPN-22 C1858T polymorphism might be a risk factor for T1D development in Saudi children. |
| تدمد: | 1532-4311 0882-0139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18266851638914fe09b012c4e8a7f334Test https://doi.org/10.1080/08820139.2018.1458109Test |
| رقم الانضمام: | edsair.doi.dedup.....18266851638914fe09b012c4e8a7f334 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324311 08820139 |
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