التفاصيل البيبلوغرافية
| العنوان: |
Leukocyte Infiltration in Cancer Creates an Unfavorable Environment for Antitumor Immune Responses: A Novel Target for Therapeutic Intervention. |
| المؤلفون: |
Bronte, Vincenzo, Cingarlini, Sara, Marigo, Ilaria, De Santo, Carmela, Gallina, Giovanna, Dolcetti, Luigi, Ugel, Stefano, Peranzoni, Elisa, Mandruzzato, Susanna, Zanovello, Paola |
| المصدر: |
Immunological Investigations; Dec2006, Vol. 35 Issue 3/4, p327-357, 31p |
| مصطلحات موضوعية: |
LEUCOCYTES, IMMUNOSUPPRESSION, IMMUNE response, CYTOKINES, FIBROBLASTS, CANCER |
| مستخلص: |
The interaction between tumor cells and the nearby environment is being actively investigated to explore how this interplay affects the initiation and progression of cancer. Host-tumor relationship results in the production of pro-inflammatory cytokines and chemokines that promote the recruitment of leukocytes within and around developing neoplasms. Cancer cells, together with newly recruited tumor-infiltrating cells, can also activate fibroblast and vascular responses, thus resulting in a chronic microenvironment perturbation. In this complex scenario, interactions between innate and adaptive immune cells can be disturbed, leading to a failure of immune-mediated tumor recognition and destruction. On the basis of the recent awareness about tumor promotion and immune deregulation by immune/inflammatory cells, novel anti-cancer strategies can be exploited. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
