التفاصيل البيبلوغرافية
| العنوان: |
Association between BoLA and subclinical bovine leukemia virus infection in a herd of Holstein-Friesian cows. |
| المؤلفون: |
Lewin, Harris, Wu, Ming-Che, Stewart, Julie, Nolan, Timothy |
| المصدر: |
Immunogenetics; 1988, Vol. 27 Issue 5, p338-344, 7p |
| مستخلص: |
The role of the bovine major histocompatibility system ( BoLA) in subclinical bovine leukemia virus (BLV) infection was investigated in a herd of Holstein-Friesian cows ( n=240). The BoLA W8.1 allele was negatively associated with the presence of antibodies to the major BLV envelope glycoprotein, BLV-gp51 (corrected P<0.001, relative risk =0.31). These results suggest that a BoLA-linked gene(s) may influence the early spread of BLV infection. Since B cells are the primary target of BLV infection, we then determined the relationship between BoLA-A locus phenotypes and B-cell numbers in peripheral blood of seropositive and seronegative cows. There were no significant differences between BoLA-A alleles for any hematological parameter in seronegative cows. Seropositive cows with the W12.1 allele had significantly greater absolute numbers of lymphocytes per microliter and B cells per microliter than did seropositive cows with other BoLA-A phenotypes ( P<0.01, respectively). The average effect associated with the W12.1 allele in BLV-infected cows was an increase of 2010 B cells per microliter of whole blood relative to BLV-infected cows with other BoLA-A phenotypes. These results demonstrate that susceptibility to the polyclonal expansion of BLV-infected B lymphocytes is associated with the W12.1 allele in Holstein-Friesian cattle. Compared with results of a previous study in a herd of Shorthorn cattle, it appears that resistance and susceptibility to subclinical progression of BLV infection are associated with different BoLA-A locus alleles in different cattle breeds. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
