التفاصيل البيبلوغرافية
| العنوان: |
Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the Thymus |
| المؤلفون: |
Schlenner, Susan M.1, Madan, Vikas1, Busch, Katrin1, Tietz, Annette1, Läufle, Carolin1, Costa, Celine1, Blum, Carmen1, Fehling, Hans Jörg1, Rodewald, Hans-Reimer1 hans-reimer.rodewald@uni-ulm.de |
| المصدر: |
Immunity (10747613). Mar2010, Vol. 32 Issue 3, p426-436. 11p. |
| مصطلحات موضوعية: |
*BONE marrow diseases, *T cells, *THYMUS, *CELL differentiation, *INTERLEUKINS, *GENE expression, *LABORATORY mice, *HEMATOPOIESIS |
| مستخلص: |
Summary: The cellular differentiation pathway originating from the bone marrow leading to early T lymphocytes remains poorly understood. The view that T cells branch off from a lymphoid-restricted pathway has recently been challenged by a model proposing a common progenitor for T cell and myeloid lineages. We generated interleukin-7 receptor α (Il7r) Cre recombinase knockin mice and traced lymphocyte development by visualizing the history of Il7r expression. Il7r fate mapping labeled all T cells but few myeloid cells. More than 85% of T cell progenitors were Il7r reporter+ and, hence, had arisen from an Il7r-expressing pathway. In contrast, the overwhelming majority of myeloid cells in the thymus were derived from Il7r reporter− cells. Thus, lymphoid-restricted progenitors are the major route to T cells, and distinct origins of lymphoid and myeloid lineages represent a fundamental hallmark of hematopoiesis. [Copyright &y& Elsevier] |
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