دورية أكاديمية
Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation
| العنوان: | Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation |
|---|---|
| المؤلفون: | Liselot Koelman, Olga Pivovarova-Ramich, Andreas F. H. Pfeiffer, Tilman Grune, Krasimira Aleksandrova |
| المصدر: | Immunity & Ageing, Vol 16, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Geriatrics |
| مصطلحات موضوعية: | Reliability, Cytokines, Multiplex platforms, Inflammaging, Biomarkers, Ageing, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Background There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers of inflammageing; however, their measurement in human samples has been challenging. This study aimed to assess the reliability of a pro- and anti-inflammatory cytokine panel in a sample of healthy people measured with a novel electrochemiluminescent multiplex immunoassay platform (Meso Scale Discovery, MSD), and to characterize their associations with metabolic and inflammatory phenotypes. Results Overall, the majority of cytokines were above the limit of detection (in at least 85.3% of the samples). Cytokines IL-6, IL-8, TNF-α, IL-10, IL-13, and IFN-γ showed overall good to fair reliability (ICC > 0.40), whereas IL-1β, IL-2, IL-4, and IL-12p70 showed poor reliability (ICC |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1742-4933 |
| العلاقة: | http://link.springer.com/article/10.1186/s12979-019-0151-1Test; https://doaj.org/toc/1742-4933Test |
| DOI: | 10.1186/s12979-019-0151-1 |
| الوصول الحر: | https://doaj.org/article/ce84e3d6a39b42f2890083f8c249f134Test |
| رقم الانضمام: | edsdoj.84e3d6a39b42f2890083f8c249f134 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17424933 |
|---|---|
| DOI: | 10.1186/s12979-019-0151-1 |