Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
| العنوان: | Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells |
|---|---|
| المؤلفون: | Benedikt Brors, Matthias Edinger, Till Strowig, Sebastian Bittner, Lisa Schmidleithner, Michael Rehli, Jens M. Werner, Lukas Prantl, Uwe Ritter, Michael Delacher, Marina Wuttke, Nicholas Strieder, Kathrin Schambeck, Markus Feuerer, Dania Riegel, Claudia Gebhard, Jochen Huehn, Agnes Hotz-Wagenblatt, Andreas Eigenberger, Thomas Hehlgans, Alexander Fischer, Asmita Pant, Florian Groeber-Becker, Petra Hoffmann, Charles D. Imbusch, Verena Schneider, Christian Schmidl, Malte Simon, Lieke Sanderink |
| المساهمون: | Publica, HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. |
| المصدر: | Immunity 720.e17 United States |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, T Follicular Helper Cells, Immunology, Population, chemical and pharmacologic phenomena, Biology, CCR8, T-Lymphocytes, Regulatory, Receptors, CCR8, Cell Line, 03 medical and health sciences, Chemokine receptor, Mice, 0302 clinical medicine, BATF, Immunology and Allergy, Animals, HaCaT Cells, Humans, education, Tissue homeostasis, education.field_of_study, Wound Healing, Gene Expression Profiling, hemic and immune systems, Cell Differentiation, Middle Aged, Chromatin, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Infectious Diseases, Basic-Leucine Zipper Transcription Factors, Gene Expression Regulation, Cell culture, 030220 oncology & carcinogenesis, Female, Wound healing |
| الوصف: | Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the transcription factor BATF. This signature, combined with gene expression profiling and TCR fate mapping, identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with nonlymphoid T follicular helper-like (Tfh-like) cells, and induction of a Tfh-like differentiation program in naive human Treg cells partially recapitulated tissue Treg regenerative characteristics, including wound healing potential. Human BATF+CCR8+ Treg cells from healthy tissue share features with tumor-resident Treg cells, highlighting the importance of understanding the context-specific functions of these cells. |
| تدمد: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2021.03.007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4f19f8f28277da2cc4e0ffce1eb289Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf4f19f8f28277da2cc4e0ffce1eb289 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10747613 |
|---|---|
| DOI: | 10.1016/j.immuni.2021.03.007 |