Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity
| العنوان: | Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity |
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| المؤلفون: | Ilseob Lee, Mee Sook Park, Jin Il Kim, Man Seong Park, Sehee Park |
| المصدر: | Immune Network |
| بيانات النشر: | The Korean Association of Immunologists, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunology, Review Article, Biology, Antigenic drift, Virus, Dengue fever, Dengue, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Antigenic variation, Immunology and Allergy, Original antigenic sin, Pathogen, Antigenic shift, medicine.disease, Virology, Influenza, 030104 developmental biology, Infectious Diseases, Vaccine, 030215 immunology |
| الوصف: | The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans. |
| اللغة: | English |
| تدمد: | 2092-6685 1598-2629 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588c6b6ef7fccc5e7a8f5f23cbd95f1bTest http://europepmc.org/articles/PMC5086450Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....588c6b6ef7fccc5e7a8f5f23cbd95f1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926685 15982629 |
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