Necrotizing fasciitis associated with sorafenib treatment
| العنوان: | Necrotizing fasciitis associated with sorafenib treatment |
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| المؤلفون: | Ho Won Kang, Seok Joong Yun, Wun-Jae Kim |
| المصدر: | IDCases, Vol 18, Iss, Pp-(2019) IDCases |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Sorafenib, medicine.medical_specialty, Hepatocellular carcinoma, Necrotizing fasciitis, 030106 microbiology, Sorafenib treatment, Adverse drug reaction, Infectious and parasitic diseases, RC109-216, urologic and male genital diseases, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, heterocyclic compounds, 030212 general & internal medicine, Fasciitis, Adverse effect, neoplasms, Tyrosine kinase inhibitors, business.industry, Surgical debridement, medicine.disease, female genital diseases and pregnancy complications, digestive system diseases, Infectious Diseases, business, medicine.drug |
| الوصف: | Highlights • There are only few case reports available on NF resulting from molecular targeted therapy. • This is the first case report of sorafenib-associated NF. • Clinicians should be aware of this possible adverse effect of molecular targeted therapy. We present here a case of extensive necrotizing fasciitis during sorafenib treatment in a patient with HBV-related hepatocellular carcinoma. Despite emergent extensive surgical debridement, the patient's clinical status progressive worsened until interruption of sorafenib therapy. The patient was successfully treated with temporal interruption of sorafenib therapy. To our knowledge, this is the first case report of sorafenib-associated necrotizing fasciitis. Given the life-threatening nature of the infection and the necessity for urgent intervention, clinicians should be aware of this possible adverse effect of tyrosine kinase inhibitors. |
| اللغة: | English |
| تدمد: | 2214-2509 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae11dcb8df67e7e58668b3144f1e593Test http://www.sciencedirect.com/science/article/pii/S2214250919301222Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ae11dcb8df67e7e58668b3144f1e593 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22142509 |
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