Synergistic effect of hypertension and smoking on the total small vessel disease score in healthy individuals: the Kashima scan study
| العنوان: | Synergistic effect of hypertension and smoking on the total small vessel disease score in healthy individuals: the Kashima scan study |
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| المؤلفون: | Tomoyuki Noguchi, Makoto Eriguchi, Yusuke Nanri, Yusuke Yakushiji, Kohei Suzuyama, Masashi Nishihara, Hideo Hara, Masanori Nishiyama, Megumi Hara, Jun Tanaka |
| المصدر: | Hypertension Research. 42:1738-1744 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Physiology, Disease, 030204 cardiovascular system & hematology, Logistic regression, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Smoking, Confounding, Odds ratio, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, Confidence interval, Cross-Sectional Studies, Cerebral Small Vessel Diseases, Hypertension, Female, Cardiology and Cardiovascular Medicine, business, Body mass index |
| الوصف: | The total cerebral small vessel disease (SVD) score is a proposed comprehensive index of SVD severity in the brain. However, data on lifestyle-related risk factors affecting SVD scores are limited. We conducted a cross-sectional study with 858 neurologically healthy adults who underwent brain magnetic resonance imaging (MRI). Information on clinical and lifestyle-related risk factors was obtained from health screenings. The SVD score (0-4) was calculated from the presence of lacunes, cerebral microbleeds, moderate to severe white matter lesions, and basal ganglia perivascular spaces on MRI. Subjects were divided into two groups by SVD score; potential risk factors and their joint effects in the two groups were assessed by logistic regression. Biologic interactions were estimated using the synergy index. After adjustment for possible confounders, the adjusted odds ratio for moderate to severe SVD scores (SVD score ≥ 2) was 1.12 (95% confidence interval (CI) 1.08-1.16) for age per year, 1.33 (95% CI 1.02-1.74) for body mass index per standard deviation, 3.39 (95% CI 1.90-6.03) for hypertension, 2.31 (95% CI 1.14-4.69) for diabetes, and 2.35 (95% CI 1.10-5.02) for smoking. Hypertension and current smoking had a synergistic effect on the risk of moderate to severe SVD (OR 10.59, 95% CI 3.97-28.3; synergy index 4.03, 95% CI 1.17-28.30), and the combination of hypertension and diabetes had an additive effect on the risk of moderate to severe SVD (OR 9.48, 95% CI 3.80-23.66; synergy index 2.12, 95% CI 0.68-6.67). Therefore, combined strategies for managing hypertension, smoking, and diabetes may be effective for preventing SVD. |
| تدمد: | 1348-4214 0916-9636 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d072a541bcd85dc8c0fa663775fc70Test https://doi.org/10.1038/s41440-019-0282-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....12d072a541bcd85dc8c0fa663775fc70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484214 09169636 |
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