Abstract P3011: Role of CD36 in Insulin Mediated Microvascular Vasodilation in African Americans
| العنوان: | Abstract P3011: Role of CD36 in Insulin Mediated Microvascular Vasodilation in African Americans |
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| المؤلفون: | Nicholas C Breier, Shea K Scudder, Cyndya A. Shibao, Dena Parsa, Nada A. Abumrad, Naji N. Abumrad, Jorge E Celedonio |
| المصدر: | Hypertension. 74 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, biology, business.industry, CD36, Internal medicine, Insulin, medicine.medical_treatment, Internal Medicine, biology.protein, medicine, Vasodilation, business |
| الوصف: | CD36 is a membrane protein involved in fatty acids uptake that is expressed in the endothelium, which has been associated with endothelial dysfunction in African Americans (AA). One in four AA is G-allele carriers for coding CD36 SNP rs3211938, which results in ~50% reduction in its expression. We reported that potentiating nitric oxide action (NO) with sildenafil restored endothelial dysfunction in conduit arteries in G-allele carriers. In this study, we tested the hypothesis that in G-allele carriers, sildenafil would improve insulin-induced microvascular recruitment (MBV) in response to fat infusion. We recruited 25 healthy AA (17 non-carriers [ages 34 ± 7.4] and eight G-allele carriers [42 ± 7.4 yrs]). Subjects underwent three visits: Visit 1: Saline infusion and hyperinsulinemic euglycemic clamp (HIE clamp). Visit 2: Lipid infusion and HIE clamp and Visit 3: Lipid infusion and HIE clamp after a four-week sildenafil treatment (60 mg/day). During each visit, the subjects underwent an assessment of MBV at baseline (bsl), after 3-hour insulin (Ins) infusion (40mu/m 2 /min) and after Ins and L-arginine (10mg/kg/min) for 30 min. infusion (Ins+L-arg). Ins+L-arg (saline day) increased the % change in MBV in both groups. However, this increase was less in carriers as compared to non-carriers (13.6±42.4 and 38.9±74.4), Fig. A. Intralipid (IL) infusion increased MBV but only in non-carriers, Fig. B . Treatment with sildenafil in the presence of IL infusion induced a decline in MBV in G-allele carriers Fig. C . In conclusion, healthy AAs with CD36 deficiency had a poor insulin-induced microvascular recruitment and appeared to be worsened by potentiating NO function with sildenafil. |
| تدمد: | 1524-4563 0194-911X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::7da3109e486f8f5ae21998c1a54f9041Test https://doi.org/10.1161/hyp.74.suppl_1.p3011Test |
| رقم الانضمام: | edsair.doi...........7da3109e486f8f5ae21998c1a54f9041 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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