Anti-Mullerian hormone indicates early ovarian decline in fragile X mental retardation (FMR1) premutation carriers: a preliminary study
| العنوان: | Anti-Mullerian hormone indicates early ovarian decline in fragile X mental retardation (FMR1) premutation carriers: a preliminary study |
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| المؤلفون: | J. Giles, Celia E. Dominguez, Julia Rohr, Stephanie L. Sherman, Weiya He, Emily G. Allen, Krista Charen |
| المصدر: | Human Reproduction. 23:1220-1225 |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Anti-Mullerian Hormone, endocrine system, medicine.medical_specialty, Adolescent, endocrine system diseases, Ovary, Primary Ovarian Insufficiency, Fragile X Mental Retardation Protein, Follicle-stimulating hormone, Internal medicine, medicine, Humans, Allele, biology, Rehabilitation, Obstetrics and Gynecology, Anti-Müllerian hormone, Middle Aged, medicine.disease, FMR1, Premature ovarian failure, Fragile X syndrome, Menopause, Endocrinology, medicine.anatomical_structure, Reproductive Medicine, Fragile X Syndrome, biology.protein, Female, Follicle Stimulating Hormone, Trinucleotide Repeat Expansion |
| الوصف: | BACKGROUND: Women who carry the fragile X mental retardation (FMR1) premutation are at risk for fragile X-associated primary ovarian insufficiency. Past studies have shown that carriers who are still cycling have increased levels FSH compared with non-carriers. As anti-Mullerian hormone (AMH) has been shown as an excellent marker of ovarian decline, we examined AMH levels among premutation carriers to characterize their ovarian function. METHODS: We determined the level of FSH and AMH in serum samples collected during early follicular phase from women who carried longer FMR1 repeat alleles (defined as � 70 repeats, n 5 40) and those with shorter repeat alleles ( |
| تدمد: | 1460-2350 0268-1161 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaab5939c3a0905d8bfa69f4c1e1abbcTest https://doi.org/10.1093/humrep/den050Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eaab5939c3a0905d8bfa69f4c1e1abbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602350 02681161 |
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