المؤلفون: Samuel J. Seguin, Angelo Poletti, Valeria Crippa, Nandini Ramesh, Elena Zelotti, Serena Carra, Jenna M. Gregory, Udai Bhan Pandey, Ilaria Bigi, Madina Baratashvili, Christopher M. Dobson, Massimo Ganassi, Maria Elena Cicardi, Chiara Diacci, Cristina Cereda

المصدر: Human Molecular Genetics
Human Molecular Genetics, 25(18), 3908-3924. Oxford University Press
Crippa, V, Cicardi, M E, Ramesh, N, Seguin, S J, Ganassi, M, Bigi, I, Diacci, C, Zelotti, E, Baratashvili, M, Gregory, J M, Dobson, C M, Cereda, C, Pandey, U B, Poletti, A & Carra, S 2016, ' The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity ', Human Molecular Genetics, vol. 25, no. 18, pp. 3908-3924 . https://doi.org/10.1093/hmg/ddw232Test

مصطلحات موضوعية: 0301 basic medicine, Protein aggregation, Eye, AMYOTROPHIC-LATERAL-SCLEROSIS, Mice, 0302 clinical medicine, AUTOPHAGIC REMOVAL, POLYGLUTAMINE TRACT, Molecular Biology, Genetics, Genetics (clinical), Drosophila Proteins, Heat-Shock Proteins, Motor Neurons, biology, Neurodegeneration, Pupa, Articles, General Medicine, Cell biology, DNA-Binding Proteins, Drosophila melanogaster, BULBAR MUSCULAR-ATROPHY, MOTOR-NEURON DISEASES, Transgene, Mice, Transgenic, Protein Serine-Threonine Kinases, Protein Aggregation, Pathological, 03 medical and health sciences, Downregulation and upregulation, Heat shock protein, mental disorders, medicine, Animals, Humans, FRONTOTEMPORAL LOBAR DEGENERATION, MUTANT ANDROGEN RECEPTOR, Amyotrophic Lateral Sclerosis, nutritional and metabolic diseases, medicine.disease, biology.organism_classification, Molecular biology, Peptide Fragments, nervous system diseases, Tissue Degeneration, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, Chaperone (protein), biology.protein, NEURODEGENERATIVE DISEASES, 030217 neurology & neurosurgery, MISFOLDED PROTEINS, Molecular Chaperones

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f35b9b239d082ddb60756ff8e436c92Test
https://doi.org/10.1093/hmg/ddw232Test

المؤلفون: Paola Rusmini, Angelo Poletti, Valeria Crippa, Maria Elena Cicardi, Elisa Giorgetti, Riccardo Cristofani, Mariarita Galbiati, A. Boncoraglio

المصدر: Human Molecular Genetics, 24(1), 64-75. Oxford University Press
Human Molecular Genetics

مصطلحات موضوعية: PC12 Cells, AMYOTROPHIC-LATERAL-SCLEROSIS, Tosyl Compounds, chemistry.chemical_compound, AUTOPHAGIC REMOVAL, Anilides, PROTEIN B8 HSPB8, KENNEDY-DISEASE, Genetics (clinical), Motor Neurons, ELONGATED POLYGLUTAMINE TRACT, Drug Synergism, Articles, General Medicine, Protein Transport, medicine.anatomical_structure, Receptors, Androgen, Dihydrotestosterone, medicine.drug, medicine.medical_specialty, KNOCK-IN MICE, Bicalutamide, 5-ALPHA-REDUCTASE TYPE-2, Bulbo-Spinal Atrophy, X-Linked, Biology, Cell Line, Gene knockin, Internal medicine, Nitriles, Autophagy, Genetics, medicine, Animals, Humans, TRANSGENIC MOUSE MODEL, Molecular Biology, Trehalose, Androgen Antagonists, medicine.disease, Rats, AGGREGATE FORMATION, Androgen receptor, Cell nucleus, Spinal and bulbar muscular atrophy, Endocrinology, chemistry, Mutation, MOTOR-NEURONS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538117ea167b3186f6106ac4f1d4103fTest
https://doi.org/10.1093/hmg/ddu419Test

المؤلفون: Mariarita Galbiati, A. Boncoraglio, Valeria Crippa, E. Bolzoni, Silvia De Biasi, Daniela Sau, E. Onesto, Angelo Poletti, Elena Fontana, Paola Rusmini, Serena Carra, Marianna Marino, Caterina Bendotti

المصدر: Human Molecular Genetics, 19(17), 3440-3456. Oxford University Press

مصطلحات موضوعية: Male, Protein Folding, animal diseases, Muscle Proteins, Gene mutation, FAMILIAL ALS, Mice, Superoxide Dismutase-1, POLYGLUTAMINE TRACT, Amyotrophic lateral sclerosis, Heat-Shock Proteins, Genetics (clinical), Motor Neurons, CHAPERONE ACTIVITY, ANDROGEN RECEPTOR, SOD1, General Medicine, chaperones, protein degradation, protein mislfolding, Cell biology, DNA-Binding Proteins, Female, SPINAL-CORD, 5-ALPHA-REDUCTASE TYPE-2, Mice, Transgenic, Protein Serine-Threonine Kinases, Protein degradation, Biology, BAG3, Cell Line, Heat shock protein, Autophagy, Genetics, medicine, Animals, Humans, HSP20 Heat-Shock Proteins, MARIE-TOOTH-DISEASE, Molecular Biology, MUTANT MICE, Superoxide Dismutase, MUTATIONS, Amyotrophic Lateral Sclerosis, nutritional and metabolic diseases, medicine.disease, nervous system diseases, Mice, Inbred C57BL, Proteasome, nervous system, Immunology, MOTOR-NEURONS, Molecular Chaperones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecb4e0d64f4f3e2259f5b127752ed80Test
https://hdl.handle.net/11370/3713ab91-fc92-4276-b50f-1ed5004a4870Test

المؤلفون: Maria Pennuto, Angelo Poletti, Isabella Palazzolo

المصدر: Human molecular genetics. 18(R1)

مصطلحات موضوعية: Neurotoxicity Syndrome, Central nervous system, Context (language use), Nerve Tissue Proteins, Biology, Animals, Humans, Neurodegenerative Diseases, Peptides, Protein Processing, Post-Translational, Genetics, Genetics (clinical), Molecular Biology, Pathogenesis, medicine, Gene, Protein Processing, Neurodegeneration, Neurotoxicity, Post-Translational, General Medicine, Polyglutamine tract, medicine.disease, Cell biology, medicine.anatomical_structure

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd6f71dac53c783d39d9812a6952417Test
https://pubmed.ncbi.nlm.nih.gov/19297400Test

المؤلفون: Daniela Sau, Paola Rusmini, Valeria Crippa, Patrizia Riso, Caterina Bendotti, E. Onesto, Marisa Porrini, Angelo Poletti, Silvia De Biasi, Silvia Simeoni, Isabella Palazzolo, E. Bolzoni, Serena Guarnieri, L. Vitellaro-Zuccarello

المصدر: Human molecular genetics. 16(13)

مصطلحات موضوعية: Cytoplasm, Proteasome Endopeptidase Complex, DNA damage, animal diseases, SOD1, Mutant, Mice, Transgenic, Biology, medicine.disease_cause, Gene Expression Regulation, Enzymologic, Superoxide dismutase, Mice, Genetics, medicine, Animals, Molecular Biology, Genetics (clinical), Loss function, Cell Nucleus, Mutation, Superoxide Dismutase, Amyotrophic Lateral Sclerosis, nutritional and metabolic diseases, General Medicine, Molecular biology, nervous system diseases, Oxygen, Cell nucleus, Oxidative Stress, medicine.anatomical_structure, nervous system, Proteasome, Microscopy, Fluorescence, Spinal Cord, biology.protein, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8270f59c73893228fc8fedd9b7364e05Test
https://pubmed.ncbi.nlm.nih.gov/17504823Test