المؤلفون: Sousounis Konstantinos, Haney Carl E, Cao Jin, Sunchu Bharath, Tsonis Panagiotis A

المصدر: Human Genomics, Vol 6, Iss 1, p 10 (2012)

مصطلحات موضوعية: 3D protein structure, Conserved motifs, Unrelated proteins, Medicine, Genetics, QH426-470

الوصف: Abstract In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.

وصف الملف: electronic resource

العلاقة: http://www.humgenomics.com/content/6/1/10Test; https://doaj.org/toc/1479-7364Test

الوصول الحر: https://doaj.org/article/1b6d1b33e8cb4f19a6afc82feb3ed117Test

المؤلفون: Bharath Sunchu, Jin Cao, Carl Edwin Haney, Konstantinos Sousounis, Panagiotis A. Tsonis

المصدر: Human Genomics, Vol 6, Iss 1, p 10 (2012)
Human Genomics

مصطلحات موضوعية: Protein Folding, lcsh:QH426-470, Unrelated proteins, Amino Acid Motifs, lcsh:Medicine, Sequence alignment, Helix-turn-helix, Review, Biology, DNA-binding protein, Conserved sequence, Histones, Hemoglobins, Drug Discovery, Genetics, Humans, Structural motif, Molecular Biology, Peptide sequence, Conserved Sequence, Helix-Turn-Helix Motifs, Zinc finger, lcsh:R, Zinc Fingers, 3D protein structure, DNA-Binding Proteins, Conserved motifs, lcsh:Genetics, Histone fold, Molecular Medicine, Sequence Alignment

الوصف: In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56da9c386b2efc3ec0dfa22a70b3cb89Test
http://www.humgenomics.com/content/6/1/10Test