Conservation of the three-dimensional structure in non-homologous or unrelated proteins
| العنوان: | Conservation of the three-dimensional structure in non-homologous or unrelated proteins |
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| المؤلفون: | Bharath Sunchu, Jin Cao, Carl Edwin Haney, Konstantinos Sousounis, Panagiotis A. Tsonis |
| المصدر: | Human Genomics, Vol 6, Iss 1, p 10 (2012) Human Genomics |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Protein Folding, lcsh:QH426-470, Unrelated proteins, Amino Acid Motifs, lcsh:Medicine, Sequence alignment, Helix-turn-helix, Review, Biology, DNA-binding protein, Conserved sequence, Histones, Hemoglobins, Drug Discovery, Genetics, Humans, Structural motif, Molecular Biology, Peptide sequence, Conserved Sequence, Helix-Turn-Helix Motifs, Zinc finger, lcsh:R, Zinc Fingers, 3D protein structure, DNA-Binding Proteins, Conserved motifs, lcsh:Genetics, Histone fold, Molecular Medicine, Sequence Alignment |
| الوصف: | In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence. |
| اللغة: | English |
| تدمد: | 1479-7364 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56da9c386b2efc3ec0dfa22a70b3cb89Test http://www.humgenomics.com/content/6/1/10Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....56da9c386b2efc3ec0dfa22a70b3cb89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14797364 |
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