Linkage mapping of CVD risk traits in the isolated Norfolk Island population
| العنوان: | Linkage mapping of CVD risk traits in the isolated Norfolk Island population |
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| المؤلفون: | Claire Bellis, John Blangero, Simon Heath, Rod A. Lea, Hannah Cox, Kimberly Begley, Thomas D. Dyer, Sharon Anne Quinlan, Lyn R. Griffiths, Jac Charlesworth |
| المصدر: | Human Genetics. 124:543-552 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Genotype, Quantitative Trait Loci, Population, location.country, Biology, Quantitative trait locus, Article, location, Risk Factors, Genetic linkage, Genetics, Humans, Genetic Predisposition to Disease, education, Genetics (clinical), Aged, Sex Characteristics, education.field_of_study, Norfolk Island, Chromosome Mapping, Middle Aged, Twin study, Genetic architecture, Pedigree, Genetics, Population, Phenotype, Cardiovascular Diseases, Chromosomes, Human, Pair 1, Female, Melanesia, Lod Score, Body mass index |
| الوصف: | To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377 individuals from the Norfolk Island population. The central aim of this research focused on the utilization of a genetically and geographically isolated population of individuals from Norfolk Island for the purposes of variance component linkage analysis to identify QTLs involved in CVD risk traits. Substantial evidence supports the involvement of traits such as systolic and diastolic blood pressures (SBP and DBP), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and triglycerides (TG) as important risk factors for CVD pathogenesis. In addition to the environmental influences of poor diet, reduced physical activity, increasing age, cigarette smoking and alcohol consumption, many studies have illustrated a strong involvement of genetic components in the CVD phenotype through family and twin studies. We undertook a genome scan using 400 markers spaced approximately 10cM in 600 individuals from Norfolk Island. Genotype data was analyzed using the variance components methods of SOLAR. Our results gave a peak LOD score of 2.01 localizing to chromosome 1p36 for systolic blood pressure and replicated previously implicated loci for other CVD relevant QTLs. |
| تدمد: | 1432-1203 0340-6717 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d744859673d78d3e1619ca5d7967eeceTest https://doi.org/10.1007/s00439-008-0580-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d744859673d78d3e1619ca5d7967eece |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321203 03406717 |
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