Soy isoflavones administered pre- and postnatally may affect the ERα and ERβ expression and elements’ content in bones of mature male rats
| العنوان: | Soy isoflavones administered pre- and postnatally may affect the ERα and ERβ expression and elements’ content in bones of mature male rats |
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| المؤلفون: | Izabela Gutowska, Iwona Noceń, Ireneusz Wiernicki, Mariola Marchlewicz, Dariusz Chlubek, Barbara Wiszniewska, Katarzyna Piotrowska, Irena Baranowska-Bosiacka |
| المصدر: | Human & Experimental Toxicology. 31:346-354 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Health, Toxicology and Mutagenesis, chemistry.chemical_element, Estrogen receptor, Calcium, Toxicology, Immunofluorescence, Pregnancy, Internal medicine, Male rats, medicine, Animals, Estrogen Receptor beta, Mineral metabolism, Femur, Rats, Wistar, SOY ISOFLAVONES, Minerals, Bone Development, Estradiol, medicine.diagnostic_test, Magnesium, Estrogen Receptor alpha, General Medicine, Immunohistochemistry, Isoflavones, Endocrinology, Animals, Newborn, Microscopy, Fluorescence, chemistry, Prenatal Exposure Delayed Effects, Female, Soybeans |
| الوصف: | The aim of this study was to assess the influence of soy isoflavones, administered pre- and later postnatally, on the estrogen receptor α (ERα) and β (ERβ) expression in bones and to examine the mineral metabolism of the skeletal system in male rats. In bones, ERs were examined with an immunohistochemical method; in blood, estradiol with chemiluminescence immunoassay and in blood and bones, calcium and magnesium with atomic absorption spectrometry and fluorides with a potentiometric method were examined. Decreased immunoexpression of ERα and the increased intensity of immunofluorescence of ERβ in osteocytes in the femur of experimental rats were observed. In the serum of treated rats, a significantly higher concentration of estradiol and lower calcium were observed. The content of magnesium and fluoride were significantly higher in the bones of the examined animals. The data presented show that pre- and postnatal supplementation of male rats with soy isoflavones may considerably increase the concentration of estrogens in serum, with a concurrent effect on the mineral composition of bones. |
| تدمد: | 1477-0903 0960-3271 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e659d47a683813800bc83b9a5b78ec95Test https://doi.org/10.1177/0960327111432501Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e659d47a683813800bc83b9a5b78ec95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770903 09603271 |
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